Scorpions from Mexico: From species diversity to venom complexity
CE Santibáñez-López, OF Francke, C Ureta… - Toxins, 2015 - mdpi.com
Scorpions are among the oldest terrestrial arthropods, which are distributed worldwide,
except for Antarctica and some Pacific islands. Scorpion envenomation represents a public …
except for Antarctica and some Pacific islands. Scorpion envenomation represents a public …
[PDF][PDF] Scorpion beta-toxins and voltage-gated sodium channels: interactions and effects
MP Escalona, LD Possani - Front Biosci (Landmark Ed), 2013 - academia.edu
Introduction 3. Voltage-gated sodium channel 4. General characteristics of the sodium
channel scorpion toxins 4.1. Electrophysiological effects of β-ScTxs on VGSCs 4.2. Voltage …
channel scorpion toxins 4.1. Electrophysiological effects of β-ScTxs on VGSCs 4.2. Voltage …
In Vivo Neutralization of α-Cobratoxin with High-Affinity Llama Single-Domain Antibodies (VHHs) and a VHH-Fc Antibody
G Richard, AJ Meyers, MD McLean… - PloS one, 2013 - journals.plos.org
Small recombinant antibody fragments (eg scFvs and VHHs), which are highly tissue
permeable, are being investigated for antivenom production as conventional antivenoms …
permeable, are being investigated for antivenom production as conventional antivenoms …
Dissecting Toxicity: The Venom Gland Transcriptome and the Venom Proteome of the Highly Venomous Scorpion Centruroides limpidus (Karsch, 1879)
JI Cid-Uribe, EP Meneses, CVF Batista, E Ortiz… - Toxins, 2019 - mdpi.com
Venom glands and soluble venom from the Mexican scorpion Centruroides limpidus
(Karsch, 1879) were used for transcriptomic and proteomic analyses, respectively. An RNA …
(Karsch, 1879) were used for transcriptomic and proteomic analyses, respectively. An RNA …
Computational methods of studying the binding of toxins from venomous animals to biological ion channels: theory and applications
D Gordon, R Chen, SH Chung - Physiological Reviews, 2013 - journals.physiology.org
The discovery of new drugs that selectively block or modulate ion channels has great
potential to provide new treatments for a host of conditions. One promising avenue revolves …
potential to provide new treatments for a host of conditions. One promising avenue revolves …
Development of a human antibody fragment cross-neutralizing scorpion toxins
JA Romero-Moreno, H Serrano-Posada… - Molecular …, 2023 - Elsevier
Previously, it was demonstrated that from the single chain fragment variable (scFv) 3F it is
possible to generate variants capable of neutralizing the Cn2 and Css2 toxins, as well as …
possible to generate variants capable of neutralizing the Cn2 and Css2 toxins, as well as …
Expression and characterization of scFv-6009FV in Pichia pastoris with improved ability to neutralize the neurotoxin Cn2 from Centruroides noxius
M Adame, H Vázquez, D Juárez-López, G Corzo… - International Journal of …, 2024 - Elsevier
Small single-chain variable fragments (scFv) are promising biomolecules to inhibit and
neutralize toxins and to act as antivenoms. In this work, we aimed to produce a functional …
neutralize toxins and to act as antivenoms. In this work, we aimed to produce a functional …
Structural and functional studies of scorpine: A channel blocker and cytolytic peptide
E López-Giraldo, E Carrillo, G Titaux-Delgado… - Toxicon, 2023 - Elsevier
Scorpine is an antimicrobial and antimalarial peptide isolated from Pandinus imperator
scorpion venom. As there are few functional and structural studies reported on scorpine-like …
scorpion venom. As there are few functional and structural studies reported on scorpine-like …
Spider and scorpion knottins targeting voltage-gated sodium ion channels in pain signaling
X Wang, H Luo, X Peng, J Chen - Biochemical pharmacology, 2024 - Elsevier
In sensory neurons that transmit pain signals, whether acute or chronic, voltage-gated
sodium channels (VGSCs) are crucial for regulating excitability. Na V 1.1, Na V 1.3, Na V …
sodium channels (VGSCs) are crucial for regulating excitability. Na V 1.1, Na V 1.3, Na V …
A single mutation in framework 2 of the heavy variable domain improves the properties of a diabody and a related single-chain antibody
ER Rodríguez-Rodríguez… - Journal of molecular …, 2012 - Elsevier
Excellent results regarding improved therapeutic properties have been often obtained
through the conversion of a single‐chain variable fragment (scFv) into a noncovalent dimeric …
through the conversion of a single‐chain variable fragment (scFv) into a noncovalent dimeric …