Scorpions are among the oldest terrestrial arthropods, which are distributed worldwide,
except for Antarctica and some Pacific islands. Scorpion envenomation represents a public …

Introduction 3. Voltage-gated sodium channel 4. General characteristics of the sodium
channel scorpion toxins 4.1. Electrophysiological effects of β-ScTxs on VGSCs 4.2. Voltage …

Small recombinant antibody fragments (eg scFvs and VHHs), which are highly tissue
permeable, are being investigated for antivenom production as conventional antivenoms …

Venom glands and soluble venom from the Mexican scorpion Centruroides limpidus
(Karsch, 1879) were used for transcriptomic and proteomic analyses, respectively. An RNA …

The discovery of new drugs that selectively block or modulate ion channels has great
potential to provide new treatments for a host of conditions. One promising avenue revolves …

Previously, it was demonstrated that from the single chain fragment variable (scFv) 3F it is
possible to generate variants capable of neutralizing the Cn2 and Css2 toxins, as well as …

Small single-chain variable fragments (scFv) are promising biomolecules to inhibit and
neutralize toxins and to act as antivenoms. In this work, we aimed to produce a functional …

Scorpine is an antimicrobial and antimalarial peptide isolated from Pandinus imperator
scorpion venom. As there are few functional and structural studies reported on scorpine-like …

In sensory neurons that transmit pain signals, whether acute or chronic, voltage-gated
sodium channels (VGSCs) are crucial for regulating excitability. Na V 1.1, Na V 1.3, Na V …

Excellent results regarding improved therapeutic properties have been often obtained
through the conversion of a single‐chain variable fragment (scFv) into a noncovalent dimeric …