Increasing interest has recently focused on determining whether several natural
compounds, collectively referred to as nutraceuticals, may exert neuroprotective actions in …

Increasing evidence suggests estrogen and estrogen signaling pathway disturbances
across psychiatric disorders. Estrogens are not only crucial in sexual maturation and …

Prodrugs are developed to increase the therapeutic properties of drugs and reduce their
side effects. Polyprodrugs emerged as highly efficient prodrugs produced by the …

Inflammatory activation of microglia is a hallmark of several disorders of the central nervous
system. In addition to protecting the brain against inflammatory insults, microglia are …

Background Women's reproductive factors have been associated with the risk of dementia;
however, these findings remain uncertain. This study aimed to examine the risk of incident …

Estradiol, either from peripheral or central origin, activates multiple molecular
neuroprotective and neuroreparative responses that, being mediated by estrogen receptors …

Objective Women have> 50% greater lifetime risk of dementia than men but the role of
female-specific endocrine milieu is not well-understood. This study evaluates associations …

Interest is growing in the potential effect of gonadal hormones, prolactin, and the
hypothalamic–pituitary–gonadal axis in schizophrenic psychoses. Many studies from …

Estrogens are the primary female sex hormones and play important roles in both
reproductive and non-reproductive systems. Estrogens can be synthesized in non …

Aim Gonadal hormones are essential for reproductive function, but can act on neural and
other organ systems, and are probably the cause of the large majority of known sex …