Background With the change of dietary habits and lifestyles, people tend to have elevated
blood uric acid levels at a younger age, and this can cause serious health problems, such as …

Gout is an inflammatory condition caused by elevated serum urate (SU), a condition known
as hyperuricemia (HU). Genetic variations, including single nucleotide polymorphisms …

In mammals, excess purine nucleosides are removed from the body by breakdown in the
liver and excretion from the kidneys. Uric acid is the end product of purine metabolism in …

Methotrexate (MTX) is the anchor disease-modifying antirheumatic drug (DMARD) in
rheumatoid arthritis (RA) treatment. It is used in monotherapy and/or in combination with …

Precision medicine is a rapidly-developing modality of medicine in human healthcare.
Based on each patient׳ s unique characteristics, more accurate dosages and drug selection …

The discovery and characterization of breast cancer resistance protein (BCRP) as an efflux
transporter conferring multidrug resistance has set off a remarkable trajectory in the …

A comprehensive guide to drug transporters that influence the absorption, distribution, and
elimination of drugs in the body The development of powerful expression cloning and …

Genome-wide association studies (GWAS) revolutionized our understanding of common
genetic variation and its impact on common human disease and traits. Developed and …

Background Gout, an inflammatory condition, is characterized by the precipitation of
monosodium urate crystals (MSU) in or around distal joints. The latter is caused by chronic …

Risk of hyperuricemia is modified by genetic and environmental factors. Our aim was to
identify factors associated with serum uric acid levels and hyperuricemia in Mexicans. A pilot …