NK cells and cancer immunosurveillance

I Waldhauer, A Steinle - Oncogene, 2008 - nature.com
Natural killer (NK) cells are lymphocytes of the innate immune system that monitor cell
surfaces of autologous cells for an aberrant expression of MHC class I molecules and cell …

Effect of NKG2D ligand expression on host immune responses

M Champsaur, LL Lanier - Immunological reviews, 2010 - Wiley Online Library
Natural killer group 2, member D (NKG2D) is an activating receptor present on the surface of
natural killer (NK) cells, some NKT cells, CD8+ cytotoxic T cells, γδ T cells, and under certain …

NKG2D ligands in tumor immunity

N Nausch, A Cerwenka - Oncogene, 2008 - nature.com
The activating receptor NKG2D (natural-killer group 2, member D) and its ligands play an
important role in the NK, γδ+ and CD8+ T-cell-mediated immune response to tumors …

Impairment of NKG2D-mediated tumor immunity by TGF-β

M Lazarova, A Steinle - Frontiers in immunology, 2019 - frontiersin.org
Transforming growth factor-β (TGF-β) suppresses innate and adaptive immune responses
via multiple mechanisms. TGF-β also importantly contributes to the formation of an …

Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation

CC Gross, A Schulte-Mecklenbeck… - Proceedings of the …, 2016 - National Acad Sciences
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous
system (CNS) resulting from a breakdown in peripheral immune tolerance. Although a …

Promiscuity and the single receptor: NKG2D

RA Eagle, J Trowsdale - Nature Reviews Immunology, 2007 - nature.com
NKG2D (natural-killer group 2, member D) is a powerful activating receptor expressed by
natural killer (NK) cells and T cells that regulates immune responses during infection, cancer …

Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK-cell …

C Cerboni, A Zingoni, M Cippitelli… - Blood, The Journal …, 2007 - ashpublications.org
Recent evidence indicates that natural killer (NK) cells can negatively regulate T-cell
responses, but the mechanisms behind this phenomenon as a consequence of NK–T-cell …

NKG2D ligands in tumor immunity: two sides of a coin

J Zhang, F Basher, JD Wu - Frontiers in immunology, 2015 - frontiersin.org
The activating/co-stimulatory receptor NKG2D (natural-killer group 2, member D) is
expressed on the surface of all human NK, NKT, CD8+ T, and subsets of γδ+ T cells. The …

NKG2D discriminates diverse ligands through selectively mechano‐regulated ligand conformational changes

J Fan, J Shi, Y Zhang, J Liu, C An, H Zhu, P Wu… - The EMBO …, 2022 - embopress.org
Stimulatory immune receptor NKG2D binds diverse ligands to elicit differential anti‐tumor
and anti‐virus immune responses. Two conflicting degeneracy recognition models based on …

HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts

J Ward, M Bonaparte, J Sacks… - Blood, The Journal …, 2007 - ashpublications.org
The ability of natural killer (NK) cells to kill virus-infected cells depends on the presence of
ligands for activation receptors on the target cells. We found the presence of few, if any …