Psychological stress elicits measurable changes in sympathetic-parasympathetic balance
and the tone of the hypothalamic-pituitary-adrenal axis, which might negatively affect the …

Glucocorticoids regulate many physiological processes and have an essential role in the
systemic response to stress. For example, gene transcription is modulated by the …

Glucocorticoids are among the most prescribed drugs worldwide for the treatment of
numerous immune and inflammatory disorders. They exert their actions by binding to the …

The characterization of the subfamily of steroid hormone receptors has enhanced our
understanding of how a set of hormonally derived lipophilic ligands controls cellular and …

Chronic excessive activation of glucocorticoid receptors induces obesity, insulin resistance,
glucose intolerance, dyslipidaemia and hypertension. Subtle abnormalities of the …

Most actions of glucocorticoids (GCs) are mediated by the glucocorticoid receptor (GR). The
interindividual response to GCs varies considerably, as demonstrated by a variable …

The glucocorticoid receptor (GR) is crucial for the effects of glucocorticoids (GCs). Several
polymorphisms of the GR are associated with altered sensitivity to GCs. For the ER22/23EK …

Glucocorticoids contribute fundamentally to the maintenance of basal and stress-related
homeostasis in all higher organisms. The major roles of these steroids in physiology are …

Natural and synthetic glucocorticoids (GCs) are widely employed in a number of
inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel …

Context: Interindividual variation in glucocorticoid (GC)-sensitivity can be partly explained by
polymorphisms in the GC receptor (GR) gene. The ER22/23EK and N363S polymorphisms …