In vivo imaging of neuroinflammation in schizophrenia

O Pasternak, M Kubicki, ME Shenton - Schizophrenia research, 2016 - Elsevier
In recent years evidence has accumulated to suggest that neuroinflammation might be an
early pathology of schizophrenia that later leads to neurodegeneration, yet the exact role in …

Translating the MAM model of psychosis to humans

G Modinos, P Allen, AA Grace, P McGuire - Trends in neurosciences, 2015 - cell.com
Elevated dopamine function and alterations in medial temporal lobe (MTL) structure and
function are two of the most robust findings in schizophrenia, but how interactions between …

Does the dopamine hypothesis explain schizophrenia?

CI Lau, HC Wang, JL Hsu, ME Liu - Reviews in the Neurosciences, 2013 - degruyter.com
The dopamine hypothesis has been the cornerstone in the research and clinical practice of
schizophrenia. With the initial emphasis on the role of excessive dopamine, the hypothesis …

Chronic social isolation decreases glutamate and glutamine levels and induces oxidative stress in the rat hippocampus

Y Shao, G Yan, Y Xuan, H Peng, QJ Huang… - Behavioural brain …, 2015 - Elsevier
Social isolation (SI) rearing of rodents is a developmental manipulation, which is commonly
compared with the psychological stressors in humans as it produces several behavioral …

[HTML][HTML] Magnetic resonance spectroscopy in schizophrenia: evidence for glutamatergic dysfunction and impaired energy metabolism

JMN Duarte, L Xin - Neurochemical research, 2019 - Springer
In the past couple of decades, major efforts were made to increase reliability of metabolic
assessments by magnetic resonance methods. Magnetic resonance spectroscopy (MRS) …

Neuroimaging for psychotherapy research: current trends

CP Weingarten, TJ Strauman - Psychotherapy Research, 2015 - Taylor & Francis
Objective: This article reviews neuroimaging studies that inform psychotherapy research. An
introduction to neuroimaging methods is provided as background for the increasingly …

[HTML][HTML] Impact of glutamate levels on neuronal response and cognitive abilities in schizophrenia

LE Falkenberg, R Westerhausen, AR Craven… - NeuroImage: Clinical, 2014 - Elsevier
Schizophrenia is characterized by impaired cognitive functioning, and brain regions
involved in cognitive control processes show marked glutamatergic abnormalities. However …

[HTML][HTML] Metabolite differences in the medial prefrontal cortex in schizophrenia patients with and without persistent auditory verbal hallucinations: a 1H MRS study

Q Wang, H Ren, C Li, Z Li, J Li, H Li, L Dai… - Translational …, 2022 - nature.com
Studies of schizophrenia (SCZ) have associated auditory verbal hallucinations (AVH) with
structural and functional abnormalities in frontal cortex, especially medial prefrontal cortex …

Association of cortical glutamate and working memory activation in patients with schizophrenia: A multimodal proton magnetic resonance spectroscopy and functional …

J Kaminski, T Gleich, Y Fukuda, T Katthagen… - Biological …, 2020 - Elsevier
Background Cognitive deficits such as working memory (WM) impairment are core features
of schizophrenia. One candidate marker for the integrity of synaptic neurotransmission …

Neuroanatomical changes in people with high schizotypy: relationship to glutamate levels

G Modinos, A Egerton, A McLaughlin… - Psychological …, 2018 - cambridge.org
BackgroundCortical glutamatergic dysfunction is thought to be fundamental for psychosis
development, and may lead to structural degeneration through excitotoxicity. Glutamate …