Total Synthesis of N-Methylwelwitindolinone D Isonitrile
Described is a concise total synthesis of N-methylwelwitindolinone D isonitrile, the first in a
family of complex bicyclo [4.3. 1] decane-containing indole alkaloids to yield to synthesis …
family of complex bicyclo [4.3. 1] decane-containing indole alkaloids to yield to synthesis …
Rapid Synthesis of the N-Methylwelwitindolinone Skeleton
An efficient, convergent synthesis of the core bicyclo [4.3. 1] decane ring system of
welwitindolinones is described. Key steps in the synthesis include an intramolecular …
welwitindolinones is described. Key steps in the synthesis include an intramolecular …
A synthesis of the welwistatin core
R Lauchli, KJ Shea - Organic Letters, 2006 - ACS Publications
An approach to the core structure of the microtubule-targeting agent welwistatin is
described. The approach utilizes the type 2 intramolecular Diels− Alder reaction, with indole …
described. The approach utilizes the type 2 intramolecular Diels− Alder reaction, with indole …
Total Synthesis of (−)-N-Methylwelwitindolinone B Isothiocyanate via a Chlorinative Oxabicycle Ring-Opening Strategy
Total Synthesis of (−)-N-Methylwelwitindolinone B Isothiocyanate via a Chlorinative Oxabicycle
Ring-Opening Strategy | Journal of the American Chemical Society ACS ACS Publications …
Ring-Opening Strategy | Journal of the American Chemical Society ACS ACS Publications …
A Unified Route to the Welwitindolinone Alkaloids: Total Syntheses of (−)-N-Methylwelwitindolinone C Isothiocyanate, (−)-N-Methylwelwitindolinone C Isonitrile, and (−)-3 …
KM Allan, K Kobayashi, VH Rawal - Journal of the American …, 2012 - ACS Publications
As part of a comprehensive strategy to the welwitindolinone alkaloids possessing a bicyclo
[4.3. 1] decane core, we report herein concise asymmetric total syntheses of (−)-N …
[4.3. 1] decane core, we report herein concise asymmetric total syntheses of (−)-N …
An approach to the total synthesis of welwistatin
TJ Greshock, RL Funk - Organic letters, 2006 - ACS Publications
An approach to the total synthesis of the antimicrotubule agent welwistatin is described. Key
transformations include (1) a 7-endo intramolecular conjugate addition reaction of enone 6 …
transformations include (1) a 7-endo intramolecular conjugate addition reaction of enone 6 …
Enantiospecific Total Synthesis of N‐Methylwelwitindolinone D Isonitrile
ED Styduhar, AD Huters, NA Weires… - Angewandte …, 2013 - Wiley Online Library
The welwitindolinone family of natural products (eg, 1, 2, Scheme1) has attracted
tremendous attention from the synthetic community over the past two decades.[1–5] Interest …
tremendous attention from the synthetic community over the past two decades.[1–5] Interest …
Chemistry of the Welwitindolinones
JC Menéndez - Bioactive Heterocycles V, 2007 - Springer
Marine cyanobacteria are a prolific source of bioactive natural products. The
welwitindolinones are a group of structurally unique metabolites isolated from …
welwitindolinones are a group of structurally unique metabolites isolated from …
Rapid access to the welwitindolinone alkaloid skeleton by cyclization of indolecarboxaldehyde substituted cyclohexanones
J Baudoux, AJ Blake, NS Simpkins - Organic Letters, 2005 - ACS Publications
A very rapid access to cyclohexanone-bridged indole systems was established by an acid-
mediated ring closure of appropriately substituted indole aldehydes, which involved an …
mediated ring closure of appropriately substituted indole aldehydes, which involved an …
Studies toward welwitindolinones: formal syntheses of N-methylwelwitindolinone C isothiocyanate and related natural products
T Fu, WT McElroy, M Shamszad, RW Heidebrecht Jr… - Tetrahedron, 2013 - Elsevier
The formal syntheses of N-methylwelwitindolinone C isothiocyanate (4) and several other
welwitindolinones 5–8 were achieved by the independent synthesis of 79. The synthesis …
welwitindolinones 5–8 were achieved by the independent synthesis of 79. The synthesis …