Described is a concise total synthesis of N-methylwelwitindolinone D isonitrile, the first in a
family of complex bicyclo [4.3. 1] decane-containing indole alkaloids to yield to synthesis …

An efficient, convergent synthesis of the core bicyclo [4.3. 1] decane ring system of
welwitindolinones is described. Key steps in the synthesis include an intramolecular …

An approach to the core structure of the microtubule-targeting agent welwistatin is
described. The approach utilizes the type 2 intramolecular Diels− Alder reaction, with indole …

Total Synthesis of (−)-N-Methylwelwitindolinone B Isothiocyanate via a Chlorinative Oxabicycle
Ring-Opening Strategy | Journal of the American Chemical Society ACS ACS Publications …

As part of a comprehensive strategy to the welwitindolinone alkaloids possessing a bicyclo
[4.3. 1] decane core, we report herein concise asymmetric total syntheses of (−)-N …

An approach to the total synthesis of the antimicrotubule agent welwistatin is described. Key
transformations include (1) a 7-endo intramolecular conjugate addition reaction of enone 6 …

The welwitindolinone family of natural products (eg, 1, 2, Scheme1) has attracted
tremendous attention from the synthetic community over the past two decades.[1–5] Interest …

Marine cyanobacteria are a prolific source of bioactive natural products. The
welwitindolinones are a group of structurally unique metabolites isolated from …

A very rapid access to cyclohexanone-bridged indole systems was established by an acid-
mediated ring closure of appropriately substituted indole aldehydes, which involved an …

The formal syntheses of N-methylwelwitindolinone C isothiocyanate (4) and several other
welwitindolinones 5–8 were achieved by the independent synthesis of 79. The synthesis …