Androgens, including testosterone and its more potent metabolite dihydrotestosterone, exert
multiple actions in the body. Physiologically, they play a critical role in male sex …

Hundreds of papers are written about hypospadias every year referring to all aspects of the
pathology, being one of the most common congenital malformations. The present study …

Microcirculation is pervasive and orchestrates a profound regulatory cross-talk with the
surrounding tissue and organs. Similarly, it is one of the earliest biological systems targeted …

Early exposure to dibutyl phthalate (DBP) can cause hypospadias in newborn foetuses.
However, the underlying molecular mechanism is not well defined. Aberrant angiogenesis is …

Di-n-butyl phthalate (DBP) is a plasticizer commonly used in industrial production and is
present in our daily life. It has been confirmed that DBP causes genitourinary malformations …

Background Recent evidence has brought the mitochondrial contact sites, in communication
with other organelles, to the centre of interest in cellular metabolism because of their …

Hypospadias results from the impaired urethral development, which is influenced by
androgens, but its genetic etiology is still unknown. Through whole exome sequencing …

The management of Differences of Sex Development (DSD) has evolved considerably in
recent years. The questioning of systematic early childhood treatment of DSD requires a …

This issue opens with the Special Article 'Twitter promotion is associated with higher citation
rates of cardiovascular articles: the ESC Journals Randomized Study'. 1 In this contribution …

Background Hypospadias is a common genital malformation among boys. Studies indicate
that hypospadias is associated with a higher risk of testicular cancer. Other forms of …