Taxol is a widely-applied anticancer drug that inhibits microtubule dynamics in actively
replicating cells. Although a minimum 19-step biosynthetic pathway has been proposed and …

The biosynthesis of natural products (NPs) is a complex dynamic spatial and temporal
process that requires the collaboration of multiple disciplines to explore the underlying …

Paclitaxel (PTX) is a high value plant natural product derived from Taxus (yew) species. This
plant specialized metabolite (PSM) and its derivatives constitute a cornerstone for the …

Paclitaxel is a famous chemotherapeutic agent, but its microbial production poses a long-
standing challenge due to its poor product selectivity. Taxadiene-5α-hydroxylase …

Autoluminescent plants have been genetically modified to express the fungal
bioluminescence pathway (FBP). However, a bottleneck in precursor production has limited …

In the quest for innovative cancer therapeutics, paclitaxel remains a cornerstone in clinical
oncology. However, its complex biosynthetic pathway, particularly the intricate oxygenation …

Resistance to paclitaxel poses a major obstacle in esophageal squamous cell carcinoma
(ESCC) treatment. A better understanding of the mechanisms underlying paclitaxel …

Paclitaxel rapidly became one of the most effective anticancer drugs. However, the
production of paclitaxel is hindered by substantial challenges, particularly considering the …

Terpenoids are vital secondary metabolites in plants that function as agents for defense and
stress resistance. These genes not only play crucial roles in plant growth and development …

Plant‐specialized metabolism is largely driven by the oxidative tailoring of key chemical
scaffolds catalyzed by cytochrome P450 (CYP450s) enzymes. Monoterpene indole alkaloids …