Analysis of aptamer discovery and technology
Aptamers are nucleic acid molecules that mimic antibodies by folding into complex 3D
shapes that bind to specific targets. Although some aptamers exist naturally as the ligand …
shapes that bind to specific targets. Although some aptamers exist naturally as the ligand …
Fc‐fusion proteins: new developments and future perspectives
DM Czajkowsky, J Hu, Z Shao… - EMBO molecular medicine, 2012 - embopress.org
Since the first description in 1989 of CD4‐Fc‐fusion antagonists that inhibit human immune
deficiency virus entry into T cells, Fc‐fusion proteins have been intensely investigated for …
deficiency virus entry into T cells, Fc‐fusion proteins have been intensely investigated for …
IgLM: Infilling language modeling for antibody sequence design
Discovery and optimization of monoclonal antibodies for therapeutic applications relies on
large sequence libraries but is hindered by developability issues such as low solubility, high …
large sequence libraries but is hindered by developability issues such as low solubility, high …
Generative language modeling for antibody design
Discovery and optimization of monoclonal antibodies for therapeutic applications relies on
large sequence libraries, but is hindered by developability issues such as low solubility, low …
large sequence libraries, but is hindered by developability issues such as low solubility, low …
Sepsis: mechanisms of bacterial injury to the patient
H Minasyan - Scandinavian journal of trauma, resuscitation and …, 2019 - Springer
In bacteremia the majority of bacterial species are killed by oxidation on the surface of
erythrocytes and digested by local phagocytes in the liver and the spleen. Sepsis-causing …
erythrocytes and digested by local phagocytes in the liver and the spleen. Sepsis-causing …
Computer-aided antibody design
D Kuroda, H Shirai, MP Jacobson… - … engineering, design & …, 2012 - academic.oup.com
Recent clinical trials using antibodies with low toxicity and high efficiency have raised
expectations for the development of next-generation protein therapeutics. However, the …
expectations for the development of next-generation protein therapeutics. However, the …
High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries
FA Fellouse, K Esaki, S Birtalan, D Raptis… - Journal of molecular …, 2007 - Elsevier
We have previously established a minimalist approach to antibody engineering by using a
phage-displayed framework to support complementarity determining region (CDR) diversity …
phage-displayed framework to support complementarity determining region (CDR) diversity …
Teaching an old scaffold new tricks: monobodies constructed using alternative surfaces of the FN3 scaffold
A Koide, J Wojcik, RN Gilbreth, RJ Hoey… - Journal of molecular …, 2012 - Elsevier
The fibronectin type III domain (FN3) has become one of the most widely used non-antibody
scaffolds for generating new binding proteins. Because of its structural homology to the …
scaffolds for generating new binding proteins. Because of its structural homology to the …
The importance of being tyrosine: lessons in molecular recognition from minimalist synthetic binding proteins
Combinatorial libraries built with severely restricted chemical diversity have yielded highly
functional synthetic binding proteins. Structural analyses of these minimalist binding sites …
functional synthetic binding proteins. Structural analyses of these minimalist binding sites …
Large-scale network analysis reveals the sequence space architecture of antibody repertoires
The architecture of mouse and human antibody repertoires is defined by the sequence
similarity networks of the clones that compose them. The major principles that define the …
similarity networks of the clones that compose them. The major principles that define the …