Hereditary hemochromatosis is an inherited iron overload disorder caused by
inappropriately low hepcidin secretion leading to increased duodenal absorption of dietary …

There is a group of beta (β)-thalassemia trait 'carriers'(with heterozygous mutations) who
should be asymptomatic with minor abnormalities in their hematological parameters, but …

Osteoporosis is one of the leading disorders among aged people. Bone loss results from a
number of physiological alterations, such as estrogen decline and aging. Meanwhile, iron …

Objectives Organ-specific hemosiderosis and iron overload complications are more serious
and more frequent in some patients with beta thalassemia major (BTM) compared with …

AIM: This study aimed to detect the most common HFE gene mutations (C282Y, H63D, and
S56C) in Egyptian beta thalassemia major patients and its relation to their iron status …

The human hemochromatosis protein HFE is encoded by the HFE gene and participates in
iron regulation. The aim of this study was to detect the most frequent HFE gene mutations in …

Background Hereditary hemochromatosis is a disorder of iron metabolism characterized by
increased iron absorption. HFE gene mutations C282Y and H63D are responsible for the …

Background: Thalassemia patients need repeated transfusion that lead to increased blood
ferritin level and iron overload in the heart and liver. Because the roles of hepcidin …

Hereditary hemochromatosis and β-thalassemia can both result in the inappropriately low
production of the hormone hepcidin, which leads to an increase in intestinal absorption and …

Objective: We aimed to investigate the effect of human hemochromatosis protein (HFE)
polymorphisms on cardiac iron overload in patients with beta-thalassemia major. Methods …