The role of cancer-associated fibroblasts and fibrosis in liver cancer
S Affo, LX Yu, RF Schwabe - Annual Review of Pathology …, 2017 - annualreviews.org
Liver cancer is the second leading cause of cancer mortality worldwide, causing more than
700,000 deaths annually. Because of the wide landscape of genomic alterations and limited …
700,000 deaths annually. Because of the wide landscape of genomic alterations and limited …
[PDF][PDF] Fibrosis‐dependent mechanisms of hepatocarcinogenesis
DY Zhang, SL Friedman - Hepatology, 2012 - Wiley Online Library
Hepatocellular carcinoma (HCC) is a rising worldwide cause of cancer mortality, making the
elucidation of its underlying mechanisms an urgent priority. The liver is unique in its …
elucidation of its underlying mechanisms an urgent priority. The liver is unique in its …
Hepatic stellate cells–from past till present: morphology, human markers, human cell lines, behavior in normal and liver pathology
RT Sufleţel, CS Melincovici, BA Gheban… - … of Morphology and …, 2021 - pmc.ncbi.nlm.nih.gov
Hepatic stellate cell (HSC), initially analyzed by von Kupffer, in 1876, revealed to be an
extraordinary mesenchymal cell, essential for both hepatocellular function and lesions …
extraordinary mesenchymal cell, essential for both hepatocellular function and lesions …
Hepatic stellate cells: central modulators of hepatic carcinogenesis
AI Thompson, KP Conroy, NC Henderson - BMC gastroenterology, 2015 - Springer
Hepatocellular carcinoma (HCC) represents the second most common cause of cancer-
related death worldwide, and is increasing in incidence. Currently, our therapeutic repertoire …
related death worldwide, and is increasing in incidence. Currently, our therapeutic repertoire …
Contributions of fibroblasts, extracellular matrix, stiffness, and mechanosensing to hepatocarcinogenesis
A Filliol, RF Schwabe - Seminars in Liver Disease, 2019 - thieme-connect.com
Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide. A
unique feature of liver cancer is its close association with liver fibrosis. About 90% of HCCs …
unique feature of liver cancer is its close association with liver fibrosis. About 90% of HCCs …
Gene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an …
Abstract Pilocytic astrocytomas (PAs) are World Health Organization Grade I gliomas; they
most often affect children and young adults and occur in patients with neurofibromatosis type …
most often affect children and young adults and occur in patients with neurofibromatosis type …
[HTML][HTML] Hepatitis C virus infection: establishment of chronicity and liver disease progression
Hepatitis C virus (HCV) often causes persistent infection, and is an important factor in the
etiology of fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). There are no preventive …
etiology of fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). There are no preventive …
S100A4 promotes hepatocellular carcinogenesis by intensifying fibrosis-associated cancer cell stemness
Y Li, J Wang, K Song, S Liu, H Zhang, F Wang… - …, 2020 - Taylor & Francis
ABSTRACT A cancer-promoting role of fibrogenesis in the liver has long been speculated;
however, the molecular mechanisms regarding this phenomenon are largely unknown. We …
however, the molecular mechanisms regarding this phenomenon are largely unknown. We …
Integrins in human hepatocellular carcinoma tumorigenesis and therapy
Q Gao, Z Sun, D Fang - Chinese medical journal, 2023 - journals.lww.com
Integrins are a family of transmembrane receptors that connect the extracellular matrix and
actin skeleton, which mediate cell adhesion, migration, signal transduction, and gene …
actin skeleton, which mediate cell adhesion, migration, signal transduction, and gene …
Common polymorphisms in angiogenesis
MS Rogers, RJ D'Amato - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
A wide variety of diseases have a significant genetic component, including major causes of
morbidity and mortality in the western world. Many of these diseases are also angiogenesis …
morbidity and mortality in the western world. Many of these diseases are also angiogenesis …