Abstract Surface Plasmon Resonance (SPR) technology has been proven to be a significant
approach for target-based drug discovery and development in the modern era. SPR unfolds …

Epistasis, the non-additive effect of mutations, can provide combinatorial improvements to
enzyme activity that substantially exceed the gains from individual mutations. Yet the …

The production of β-lactamases is a prevalent mechanism that poses serious pressure on
the control of bacterial resistance. Furthermore, the unavoidable and alarming increase in …

Cucurbitacin B (CuB) is a potent but toxic anticancer natural product. Herein, we designed
and synthesized 2-OH-and 16-OH-modified CuB derivatives to improve their antitumor …

Infections due to carbapenemase-producing Gram-negative pathogens are associated with
limited treatment options and consequently lead to increased mortality and morbidity. In …

Bacterial resistance to β-lactam antibiotics is largely mediated by β-lactamases, which
catalyze the hydrolysis of these drugs and continue to emerge in response to antibiotic use …

β-Lactamase enzymes hydrolyze and thereby provide bacterial resistance to the important β-
lactam class of antibiotics. The OXA-48 and NDM-1 β-lactamases cause resistance to the …

Zinc ion-dependent β-lactamases (MBLs) catalyze the hydrolysis of almost all β-lactam
antibiotics and resist the action of clinically available β-lactamase inhibitors. We report how …

B-cell lymphoma 6 (BCL6) is a master regulator of germinal center formation that produce
antibody-secreting plasma cells and memory B-cells for sustained immune responses. The …

B-cell lymphoma 6 (BCL6) is a transcriptional factor that expresses in lymphocytes and
regulates the differentiation and proliferation of lymphocytes. Therefore, BCL6 is a …