Circadian rhythms in haematological malignancies: therapeutic potential and personalised interventions

M Motiei, R Abu-Dawud, A Relógio, C Assaf - Ebiomedicine, 2024 - thelancet.com
The circadian clock, a fundamental cellular mechanism, regulates the rhythmic expression of
numerous genes and biological processes across various organs. Disruptions in this …

WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

K Mitchell, SA Sprowls, S Arora, S Shakya… - Genes & …, 2023 - genesdev.cshlp.org
Glioblastomas (GBMs) are heterogeneous, treatment-resistant tumors driven by populations
of cancer stem cells (CSCs). However, few molecular mechanisms critical for CSC …

An In Vitro Model for Acute Myeloid Leukemia Relapse Using the SORE6 Reporter

J Lai, C Shang, W Chen, I Izevbaye, MP Chu… - International Journal of …, 2023 - mdpi.com
Many patients diagnosed with acute myeloid leukemia (AML) relapse within two years of the
initial remission. The biology of AML relapse is incompletely understood, although cancer …

A live single-cell reporter system reveals drug-induced plasticity of a cancer stem cell-like population in cholangiocarcinoma

K Kongtanawanich, S Prasopporn, S Jamnongsong… - Scientific Reports, 2024 - nature.com
Cancer stem cells (CSC) play an important role in carcinogenesis and are acknowledged to
be responsible for chemoresistance in cholangiocarcinoma (CCA). Studying CCA CSC has …

ULK2 Is a Key Pro-Autophagy Protein That Contributes to the High Chemoresistance and Disease Relapse in FLT3-Mutated Acute Myeloid Leukemia

J Lai, C Yang, C Shang, W Chen, MP Chu… - International Journal of …, 2024 - mdpi.com
We recently demonstrated that a small subset of cells in FLT3-mutated acute myeloid
leukemia (AML) cell lines exhibit SORE6 reporter activity and cancer stem-like features …

Multivalent DNA-encoded lectins on phage enable detecting compositional glycocalyx differences

GM Lima, ZJ Chenarboo, M Sojitra, S Sarkar… - bioRxiv, 2023 - biorxiv.org
Selective detection of disease-associated changes in the cellular glycocalyx is a foundation
of modern targeted therapies. Detecting minor changes in the density and identity of glycans …

Explorando a quinase aurora A como alvo terapêutico em células iniciadoras de tumor pulmonares induzidas por KRAS

LC Scalabrini - 2022 - teses.usp.br
O câncer de pulmão é o câncer que mais mata no mundo todo, e um dos fenótipos mais
importantes da oncogênese é a aquisição e conservação de um fenótipo tronco tumoral …

[PDF][PDF] Expression of Embryonic Stem Cell Markers in Childhood Neuroblastoma and Glioblastoma Cancer Cell Lines

M Al Mohaini, F Al Hejji, Z Al Hamar, SA Abohelaika… - 2023 - researchgate.net
Cancer in childhood ages have significant differences from adult cancer in the incidence
rate, type and location of cancer, pathophysiology, progression of tumor, management plan …

Correction: Li et al. Identification and Characterization of Cancer Stem-Like Cells in ALK-Positive Anaplastic Large Cell Lymphoma Using the SORE6 Reporter. Curr …

J Li, M Haque, C Shang, B Hassan, D Liu… - Current Issues in …, 2022 - mdpi.com
CIMB | Free Full-Text | Correction: Li et al. Identification and Characterization of Cancer
Stem-Like Cells in ALK-Positive Anaplastic Large Cell Lymphoma Using the SORE6 Reporter …

The liquid lectin array detects compositional glycocalyx differences using multivalent DNA-encoded lectins on phage

GM Lima, Z Jame-Chenarboo, M Sojitra, S Sarkar… - Chemistry & Biology, 2024 - cell.com
Selective detection of disease-associated changes in the glycocalyx is an emerging field in
modern targeted therapies. Detecting minor glycan changes on the cell surface is a …