Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. In
this study, we establish that aging of the immune system, regardless of the age of the stroma …

Clonal hematopoiesis, a condition in which acquired somatic mutations in hematopoietic
stem cells lead to the outgrowth of a mutant hematopoietic clone, is associated with a higher …

Clonal haematopoiesis of indeterminate potential (CHIP) is a preclinical condition wherein a
sizeable proportion of an individual's circulating blood cells are derived from a single …

Background Maintaining low concentrations of plasma low‐density lipoprotein cholesterol
(LDLc) over time decreases the number of LDL particles trapped within the artery wall, slows …

Purpose: Solid organ transplant recipients comprise a unique population of
immunosuppressed patients with increased risk of malignancy, including hematologic …

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) is an acquired
genetic risk factor for both leukemia and cardiovascular disease. It results in proinflammatory …

Background Obesity is accompanied by dysregulated inflammation, which can contribute to
vasculometabolic complications including metabolic syndrome and atherosclerosis …

The study of somatic mutations and the associated clonal mosaicism across the human body
has transformed our understanding of aging and its links to cancer. In proliferative human …

The increased sensitivity of novel DNA sequencing techniques has made it possible to
identify somatic mutations in small circulating clones of haematopoietic stem cells. When the …

The cardiovascular complications of atherosclerosis are thought to arise from an
inflammatory response to the accumulation of cholesterol-rich lipoproteins in the arterial …