Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone
homeostasis, which is maintained by an intricate balance between bone formation and bone …

Skeletal muscle and bone share common embryological origins from mesodermal cell
populations and also display common growth trajectories early in life. Moreover, muscle and …

Aging at the cellular level is a complex process resulting from accumulation of various
damages leading to functional impairment and a reduced quality of life at the level of the …

Introduction• Bone fracture healing and healing problems• Biomaterial scaffolds and tissue
engineering in bone formation‐Bone tissue engineering‐Biomaterial scaffolds‐Synthetic …

Human aging is associated with bone loss leading to bone fragility and increased risk of
fractures. The cellular and molecular causes of age‐related bone loss are current intensive …

Progenitor cells such as mesenchymal stem cells (MSCs) have elicited great hopes for
therapeutic augmentation of physiological regeneration processes, eg, for bone fracture …

A decline in bone mass leading to an increased fracture risk is a common feature of age-
related bone changes. The mechanisms underlying bone senescence are very complex and …

Peptidylarginine deiminase (PADI) 2 catalyzes the post-translational conversion of peptidyl-
arginine to peptidyl-citrulline in a process called citrullination. However, the precise …

Obesity is associated with increased risk for fragility fractures. However, the cellular
mechanisms are unknown. Using a translational approach combining RNA sequencing and …

The pace of repair declines with age and, while exposure to a young circulation can
rejuvenate fracture repair, the cell types and factors responsible for rejuvenation are …