As brain and bone disorders represent major health issues worldwide, substantial clinical
investigations demonstrated a bidirectional crosstalk on several levels, mechanistically …

Aging, obesity, and insulin resistance are known to cause the impairment of bone regulation,
resulting in an imbalance in bone homeostasis and pathological bone. The natural …

Endocannabinoids (eCBs) are internal lipid mediators recognized by the cannabinoid-1 and-
2 receptors (CB 1 R and CB 2 R, respectively), which also mediate the different …

Over the past decades, emerging evidence in the literature has demonstrated that the
innervation of bone is a crucial modulator for skeletal physiology and pathophysiology. The …

The endocannabinoid system (ECS) dynamically regulates many aspects of mammalian
physiology. ECS has gained substantial interest since growing evidence suggests that it …

Abstract Cannabidiol (CBD), the non-psychoactive component of the Cannabis sativa plant,
is marketed as a potential therapeutic agent and has been studied for its roles in reducing …

There are two well-characterized cannabinoid receptors (CB1R and CB2R and other
candidates): the central nervous system (CNS) enriched CB1R and peripheral tissue …

High-calorie diets and chronic stress are major contributors to the development of obesity
and metabolic disorders. These two risk factors regulate the activity of the sympathetic …

Context The endocannabinoid system uses tissue-specific lipid ligands and G protein‒
coupled transmembrane receptors to regulate neurologic, metabolic, and immune …

In addition to its recognized role in providing structural support, bone plays a crucial role in
maintaining the functionality and balance of various organs by secreting specific cytokines …