Toward developing human organs via embryo models and chimeras

J Wu, J Fu - Cell, 2024 - cell.com
Developing functional organs from stem cells remains a challenging goal in regenerative
medicine. Existing methodologies, such as tissue engineering, bioprinting, and organoids …

Generation of rat forebrain tissues in mice

J Huang, B He, X Yang, X Long, Y Wei, L Li, M Tang… - Cell, 2024 - cell.com
Interspecies blastocyst complementation (IBC) provides a unique platform to study
development and holds the potential to overcome worldwide organ shortages. Despite …

Global analysis of contact-dependent human-to-mouse intercellular mRNA and lncRNA transfer in cell culture

S Dasgupta, DY Dayagi, G Haimovich, E Wyler… - Elife, 2023 - elifesciences.org
Full-length mRNAs transfer between adjacent mammalian cells via direct cell-to-cell
connections called tunneling nanotubes (TNTs). However, the extent of mRNA transfer at the …

Inter-cellular mRNA Transfer Alters Human Pluripotent Stem Cell State

Y Yoneyama, RR Zhang, M Kimura, Y Cai, M Adam… - bioRxiv, 2024 - biorxiv.org
Inter-cellular transmission of mRNA is being explored in mammalian species using immortal
cell lines. Here, we uncover an inter-cellular mRNA transfer phenomenon that allows for the …