The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

The ECM (extracellular matrix) network plays a crucial role in cardiac homeostasis, not only
by providing structural support, but also by facilitating force transmission, and by transducing …

Abstract Angiotensin-converting enzyme 2 (ACE2) has proven beneficial in attenuating
diabetic cardiomyopathy (DCM) but has been found to be a substrate of a disintegrin and …

Thirty years ago, a novel axis of the renin-angiotensin system (RAS) was unveiled by the
discovery of angiotensin-(1− 7)[ANG-(1− 7)] generation in vivo. Later, angiotensin …

The glycocalyx is a polysaccharide structure that protrudes from the body of a cell. It is
primarily conformed of glycoproteins and proteoglycans, which provide communication …

The disintegrin metalloprotease ADAM17 has been a matter of intense studies aiming to
unravel structure, function and regulation of protease expression, maturation and activity. In …

2 Hypertension May 2018 acknowledged in VSMCs, whether it has any significance in
vascular pathophysiology linked to angiotensin II had not been studied. Recently, our group …

Myocardial fibrosis is excess accumulation of the extracellular matrix fibrillar collagens.
Fibrosis is a key feature of various cardiomyopathies and compromises cardiac systolic and …

The apelin pathway has emerged as a critical regulator of cardiovascular homeostasis and
disease. However, the exact role of pyr1-apelin-13 in angiotensin (Ang) II–mediated heart …

ADAM17 is a member of the a disintegrin and metalloproteinase (ADAM) family of
transmembrane proteases involved in the shedding of some cell membrane proteins and …