Hypoxia is a hallmark of all solid tumors and their metastases. This leads to activation of the
hypoxia-inducible factor (HIF) family of transcription factors, which modulate gene …

Understanding nephron loss is a primary strategy for preventing CKD progression. Death of
renal tubular cells may occur by apoptosis during developmental and regenerative …

Ferroptosis is a non-apoptotic form of regulated cell death that is triggered by the
discoordination of regulatory redox mechanisms culminating in massive peroxidation of …

Microbial dysbiosis is a colorectal cancer (CRC) hallmark and contributes to inflammation,
tumor growth, and therapy response. Gut microbes signal via metabolites, but how the …

Objectives Chondrocyte ferroptosis contributes to osteoarthritis (OA) progression, and D‐
mannose shows therapeutic value in many inflammatory conditions. Here, we investigated …

Solid tumors have developed robust ferroptosis resistance. The mechanism underlying
ferroptosis resistance regulation in solid tumors, however, remains elusive. Here, we report …

Ferroptosis is triggered by intracellular iron leading to accumulation of lipid peroxidation
consequent promotion of cell death. Cancer cell exhibits ability to evade ferroptosis by …

Oxidative stress and hypoxia in the retinal pigment epithelium (RPE) have long been
considered major risk factors in the pathophysiology of age-related macular degeneration …

Oxygen is crucial for life and acts as the final electron acceptor in mitochondrial energy
production. Cells adapt to varying oxygen levels through intricate response systems …

The change in climatic conditions is the major cause for decline in crop production
worldwide. Decreasing crop productivity will further lead to increase in global hunger rate …