Background Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have
emerged as a powerful tool for disease modeling, though their immature nature currently …

Hypertrophic cardiomyopathy (HCM), the most common inherited heart disease, is still
orphan of a specific drug treatment. The erroneous consideration of HCM as a rare disease …

The hypertrophic cardiomyopathy phenotype encompasses a heterogeneous spectrum of
genetic and acquired diseases characterized by the presence of left ventricular hypertrophy …

Drug-induced cardiotoxicity and hepatotoxicity are major causes of drug attrition. To
decrease late-stage drug attrition, pharmaceutical and biotechnology industries need to …

The prevailing notion that reduced cofactors NADH and FADH 2 transfer electrons from the
tricarboxylic acid cycle to the mitochondrial electron transfer system creates ambiguities …

Cardiac metabolism represents a crucial and essential connecting bridge between the
healthy and diseased heart. The cardiac muscle, which may be considered an omnivore …

The ability § of the heart to adapt to changes in the mechanical environment is critical for
normal cardiac physiology. The role of nitric oxide is increasingly recognized as a mediator …

Background With the disappointing results associated with the use of cardiac myosin
inhibitors in the treatment of hypertrophic cardiomyopathy (HCM), the development of new …

Introduction Cardiomyopathies are complex heart diseases with significant prevalence
around the world. Among these, primary forms are the major contributors to heart failure and …

Hypertrophic cardiomyopathy (HCM) is the most common hereditary cardiomyopathy. It is
often caused by mutations of genes encoding for sarcomeric or sarcomere-associated …