SERCA2a: a key protein in the Ca2+ cycle of the heart failure
L Zhihao, N Jingyu, L Lan, S Michael, G Rui, B Xiyun… - Heart failure …, 2020 - Springer
Abstract Calcium ion (Ca 2+) cycle plays a crucial role in the contraction and relaxation of
cardiomyocytes. The sarcoplasmic reticulum (SR) acts as an organelle for storing Ca 2+ …
cardiomyocytes. The sarcoplasmic reticulum (SR) acts as an organelle for storing Ca 2+ …
Ca2+ mishandling and mitochondrial dysfunction: a converging road to prediabetic and diabetic cardiomyopathy
C Jaquenod De Giusti, J Palomeque… - Pflügers Archiv-European …, 2022 - Springer
Diabetic cardiomyopathy is defined as the myocardial dysfunction that suffers patients with
diabetes mellitus (DM) in the absence of hypertension and structural heart diseases such as …
diabetes mellitus (DM) in the absence of hypertension and structural heart diseases such as …
Calcium‐calmodulin‐dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance
M Federico, EL Portiansky, L Sommese… - The Journal of …, 2017 - Wiley Online Library
Key points Spontaneous sarcoplasmic reticulum (SR) Ca2+ release events increased in
fructose‐rich diet mouse (FRD) myocytes vs. control diet (CD) mice, in the absence of …
fructose‐rich diet mouse (FRD) myocytes vs. control diet (CD) mice, in the absence of …
Unbalance Between Sarcoplasmic Reticulum Ca2 + Uptake and Release: A First Step Toward Ca2 + Triggered Arrhythmias and Cardiac Damage
The present review focusses on the regulation and interplay of cardiac SR Ca2+ handling
proteins involved in SR Ca2+ uptake and release, ie, SERCa2/PLN and RyR2. Both RyR2 …
proteins involved in SR Ca2+ uptake and release, ie, SERCa2/PLN and RyR2. Both RyR2 …
Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive …
CA Valverde, G Mazzocchi, MN Di Carlo… - Cardiovascular …, 2019 - academic.oup.com
Abstract Aims Abnormal Ca2+ release from the sarcoplasmic reticulum (SR), associated with
Ca2+-calmodulin kinase II (CaMKII)-dependent phosphorylation of RyR2 at Ser2814, has …
Ca2+-calmodulin kinase II (CaMKII)-dependent phosphorylation of RyR2 at Ser2814, has …
Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model of phospholamban R14del cardiomyopathy
Abstract The heterozygous Phospholamban p. Arg14del mutation is found in patients with
dilated or arrhythmogenic cardiomyopathy. This mutation triggers cardiac contractile …
dilated or arrhythmogenic cardiomyopathy. This mutation triggers cardiac contractile …
Ca2+/calmodulin-dependent kinase II-dependent regulation of atrial myocyte late Na+ current, Ca2+ cycling, and excitability: a mathematical modeling study
Atrial fibrillation (AF) affects more than three million people per year in the United States and
is associated with high morbidity and mortality. Both electrical and structural remodeling …
is associated with high morbidity and mortality. Both electrical and structural remodeling …
Determinants of Ca2+ release restitution: Insights from genetically altered animals and mathematical modeling
A Cely-Ortiz, JI Felice, LA Díaz-Zegarra… - Journal of general …, 2020 - rupress.org
Each heartbeat is followed by a refractory period. Recovery from refractoriness is known as
Ca2+ release restitution (CRR), and its alterations are potential triggers of Ca2+ …
Ca2+ release restitution (CRR), and its alterations are potential triggers of Ca2+ …
Conditional up-regulation of SERCA2a exacerbates RyR2-dependent ventricular and atrial arrhythmias
Ryanodine receptor 2 (RyR2) and SERCA2a are two major players in myocyte calcium (Ca)
cycling that are modulated physiologically, affected by disease and thus considered to be …
cycling that are modulated physiologically, affected by disease and thus considered to be …
When signalling goes wrong: pathogenic variants in structural and signalling proteins causing cardiomyopathies
M Ehsan, H Jiang, K L. Thomson… - Journal of Muscle …, 2017 - Springer
Cardiomyopathies are a diverse group of cardiac disorders with distinct phenotypes,
depending on the proteins and pathways affected. A substantial proportion of …
depending on the proteins and pathways affected. A substantial proportion of …