Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …

A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can
be sensed by specific sensors, then trigger a series of signal transduction pathways and …

Osteoarthritis (OA) is an age-related metabolic disease. Low-grade inflammation and
oxidative stress are the last common pathway of OA. α-ketoglutarate (α-KG) is an essential …

The Warburg effect is the long-standing riddle of cancer biology. How does aerobic
glycolysis, inefficient in producing ATP, confer a growth advantage to cancer cells? A new …

Tumor metabolism is emerging as a potential target for cancer therapies. This new approach
holds particular promise for the treatment of glioblastoma, a highly lethal brain tumor that is …

Hypoxia-inducible factor (HIF) directly activates the transcription of metabolic enzymes in
response to hypoxia to reprogram cellular metabolism required for tumor cell proliferation …

Simple Summary Many types of cancer cells utilize the common amino acid l-glutamine to
maintain their metabolic demands for energy and the nitrogen required for DNA synthesis …

Branched-chain amino acid aminotransferases, widely present in natural organisms,
catalyze bidirectional amino transfer between branched-chain amino acids and branched …

Third-generation EGFR tyrosine kinase inhibitors (TKIs), exemplified by osimertinib, have
demonstrated promising clinical efficacy in the treatment of non-small cell lung cancer …

Glioma, a malignant and infiltrative neoplasm of the central nervous system, poses a
significant threat due to its high mortality rates. Branched-chain amino acid transaminase 1 …