Uncertainty about a possible future threat disrupts our ability to avoid it or to mitigate its
negative impact and thus results in anxiety. Here, we focus the broad literature on the …

Anxiety disorders are a significant problem in the community, and recent neuroimaging
research has focused on determining the brain circuits that underlie them. Research on the …

The cerebellum has been considered for a long time to play a role solely in motor
coordination. However, studies over the past two decades have shown that the cerebellum …

Stress-induced changes in the immune system, which lead to neuroinflammation and
consequent brain alterations, have been suggested as possible neurobiological substrates …

Panic disorder is a common mental disorder that affects up to 5% of the population at some
point in life. It is often disabling, especially when complicated by agoraphobia, and is …

Brain imaging techniques allow the in vivo evaluation of the human brain, leading to a better
understanding of its anatomical, functional and metabolic substrate. The aim of this current …

Advances in neuroimaging techniques over the past two decades have allowed scientists to
investigate the neurocircuitry of anxiety disorders. Such research has implicated the …

Anxiety is characterized by the anticipation of aversive future events. The importance of
prestimulus anticipatory factors, such as goals and expectations, is well-established in both …

Although the cerebellum is traditionally known for its role in motor functions, recent evidence
points toward the additional involvement of the cerebellum in an array of non-motor …

In 2000, Gorman et al. published a widely acknowledged revised version of their 1989
neuroanatomical hypothesis of panic disorder (PD). Herein, a 'fear network'was suggested …