ATP‐binding cassette (ABC) transporters in cancer: A review of recent updates
The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …
Aurora kinase B inhibition: a potential therapeutic strategy for cancer
NA Borah, MM Reddy - Molecules, 2021 - mdpi.com
Aurora kinase B (AURKB) is a mitotic serine/threonine protein kinase that belongs to the
aurora kinase family along with aurora kinase A (AURKA) and aurora kinase C (AURKC) …
aurora kinase family along with aurora kinase A (AURKA) and aurora kinase C (AURKC) …
Unveiling the mechanisms and challenges of cancer drug resistance
Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer
treatment strategies are evolving due to innate and acquired resistance capacity, governed …
treatment strategies are evolving due to innate and acquired resistance capacity, governed …
Novel inhibitor-based therapies for thyroid cancer—An update
M Ratajczak, D Gaweł, M Godlewska - International journal of molecular …, 2021 - mdpi.com
Thyroid cancers (TCs) are the most common tumors of the endocrine system and a constant
rise in the number of TC cases has been observed for the past few decades. TCs are one of …
rise in the number of TC cases has been observed for the past few decades. TCs are one of …
The battlefield of chemotherapy in pediatric cancers
Simple Summary The survival rate for pediatric cancers has improved significantly over the
last decades. Conventional chemotherapies play a vital role in pediatric cancer treatment …
last decades. Conventional chemotherapies play a vital role in pediatric cancer treatment …
Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma
W Ali, S Garbo, A Kincses, M Nové, G Spengler… - European Journal of …, 2022 - Elsevier
Lymphomas are still difficult to treat even with modern therapies as, among others, multidrug
resistance (MDR) is often counteracting a successful cancer therapy. P-gp/ABC-transporters …
resistance (MDR) is often counteracting a successful cancer therapy. P-gp/ABC-transporters …
Overexpression of ABCB1 associated with the resistance to the KRAS-G12C specific inhibitor ARS-1620 in cancer cells
The KRAS-G12C inhibitor ARS-1620, is a novel specific covalent inhibitor of KRAS-G12C,
possessing a strong targeting inhibitory effect on KRAS-G12C mutant tumors …
possessing a strong targeting inhibitory effect on KRAS-G12C mutant tumors …
The resistance of cancer cells to palbociclib, a cyclin-dependent kinase 4/6 inhibitor, is mediated by the ABCB1 transporter
Palbociclib was approved by the United States Food and Drug Administration for use, in
combination with letrozole, as a first-line treatment for estrogen receptor-positive/human …
combination with letrozole, as a first-line treatment for estrogen receptor-positive/human …
[HTML][HTML] MET inhibitor tepotinib antagonizes multidrug resistance mediated by ABCG2 transporter: In vitro and in vivo study
Overexpression of ABCG2 transporter in cancer cells has been linked to the development of
multidrug resistance (MDR), an obstacle to cancer therapy. Our recent study uncovered that …
multidrug resistance (MDR), an obstacle to cancer therapy. Our recent study uncovered that …
Establishment and characterization of a novel multidrug resistant human ovarian cancer cell line with heterogenous MRP7 overexpression
Ovarian cancer is one of the leading female malignancies which accounts for the highest
mortality rate among gynecologic cancers. Surgical cytoreduction followed by chemotherapy …
mortality rate among gynecologic cancers. Surgical cytoreduction followed by chemotherapy …