Since their establishment thirty years ago, THP-1 cells have become one of most widely
used cell lines to investigate the function and regulation of monocytes and macrophages in …

Cardiovascular disease is the biggest killer globally and the principal contributing factor to
the pathology is atherosclerosis; a chronic, inflammatory disorder characterized by lipid and …

Chronic low-grade inflammation is a common hallmark of the aging process and many age-
related diseases. There is substantial evidence that persistent inflammation is associated …

The phenotype of macrophages in atherosclerotic lesions can vary dramatically, from a large
lipid laden foam cell to a small inflammatory cell. Classically, the concept of macrophage …

Atherosclerosis is primarily a disorder of lipid metabolism, but there is also a prominent
chronic inflammatory component that drives the atherosclerotic lesion progression in the …

The development of atherosclerosis, a chronic inflammatory disease characterized by the
formation of arterial fibrotic plaques, has been shown to be reduced by IL-33 in vivo …

Effective innate immunity against many microbial pathogens requires macrophage programs
that upregulate phagocytosis and direct antimicrobial pathways, two functions generally …

Background and aims The aim of this study was to perform a systematic review of the
association between DNA methylation and coronary heart disease (CHD) or related …

Although the understanding of the underlying pathology of atherosclerosis has improved in
recent years, the disease is still the main cause of death globally. Current evidence has …

Leprosy is a chronic infectious disease caused by Mycobacterium leprae. According to
official reports from 121 countries across five WHO regions, there were 213 899 newly …