Rheumatoid arthritis—common origins, divergent mechanisms

EM Gravallese, GS Firestein - New England Journal of Medicine, 2023 - Mass Medical Soc
Rheumatoid Arthritis — Common Origins, Divergent Mechanisms | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Synovial tissue macrophages in joint homeostasis, rheumatoid arthritis and disease remission

M Kurowska-Stolarska, S Alivernini - Nature Reviews Rheumatology, 2022 - nature.com
Synovial tissue macrophages (STMs) were principally recognized as having a pro-
inflammatory role in rheumatoid arthritis (RA), serving as the main producers of pathogenic …

Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial

F Rivellese, AEA Surace, K Goldmann, E Sciacca… - Nature medicine, 2022 - nature.com
Patients with rheumatoid arthritis (RA) receive highly targeted biologic therapies without
previous knowledge of target expression levels in the diseased tissue. Approximately 40 …

[HTML][HTML] Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes

F Zhang, AH Jonsson, A Nathan, N Millard, M Curtis… - Nature, 2023 - nature.com
Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation
and destruction. There is currently no cure for rheumatoid arthritis, and the effectiveness of …

Rheumatoid arthritis: advances in treatment strategies

P Prasad, S Verma, Surbhi, NK Ganguly… - Molecular and cellular …, 2023 - Springer
Rheumatoid arthritis (RA) is characterised by severe joint and bone damage due to
heightened autoimmune response at the articular sites. Worldwide annual incidence and …

COVID-19 and the Swedish enigma

M Claeson, S Hanson - The Lancet, 2021 - thelancet.com
In the second wave of the COVID-19 pandemic, the Swedish national response continues to
be an outlier with cases and deaths increasing more rapidly than in its Nordic neighbours. 1 …

Psoriatic arthritis: pathogenesis and targeted therapies

AB Azuaga, J Ramírez, JD Cañete - International journal of molecular …, 2023 - mdpi.com
Psoriatic arthritis (PsA), a heterogeneous chronic inflammatory immune-mediated disease
characterized by musculoskeletal inflammation (arthritis, enthesitis, spondylitis, and …

Efficacy of synthetic and biological DMARDs: a systematic literature review informing the 2022 update of the EULAR recommendations for the management of …

A Kerschbaumer, A Sepriano, SA Bergstra… - Annals of the …, 2023 - ard.bmj.com
Objectives To update the evidence on efficacy of DMARDs (disease-modifying antirheumatic
drugs) and inform the taskforce of the 2022 update of the European Alliance of Associations …

The promise of precision medicine in rheumatology

JM Guthridge, CA Wagner, JA James - Nature medicine, 2022 - nature.com
Systemic autoimmune rheumatic diseases (SARDs) exhibit extensive heterogeneity in
clinical presentation, disease course, and treatment response. Therefore, precision …

Role of reactive oxygen species and mitochondrial damage in rheumatoid arthritis and targeted drugs

W Jing, C Liu, C Su, L Liu, P Chen, X Li… - Frontiers in …, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial
inflammation, pannus formation, and bone and cartilage damage. It has a high disability …