Mesenchymal condensation in tooth development and regeneration: a focus on translational aspects of organogenesis

BD Sui, CX Zheng, WM Zhao, K Xuan… - Physiological …, 2023 - journals.physiology.org
The teeth are vertebrate-specific, highly specialized organs performing fundamental
functions of mastication and speech, the maintenance of which is crucial for orofacial …

Intertwined signaling pathways governing tooth development: a give-and-take between canonical Wnt and Shh

F Hermans, L Hemeryck, I Lambrichts… - Frontiers in cell and …, 2021 - frontiersin.org
Teeth play essential roles in life. Their development relies on reciprocal interactions
between the ectoderm-derived dental epithelium and the underlying neural crest-originated …

SARS-CoV-2 infection of the oral cavity and saliva

N Huang, P Pérez, T Kato, Y Mikami, K Okuda… - Nature medicine, 2021 - nature.com
Despite signs of infection—including taste loss, dry mouth and mucosal lesions such as
ulcerations, enanthema and macules—the involvement of the oral cavity in coronavirus …

Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis

J Jing, J Feng, Y Yuan, T Guo, J Lei, F Pei… - Nature …, 2022 - nature.com
Cranial neural crest cells are an evolutionary innovation of vertebrates for craniofacial
development and function, yet the mechanisms that govern the cell fate decisions of …

Single-cell census of human tooth development enables generation of human enamel

A Alghadeer, S Hanson-Drury, AP Patni, DD Ehnes… - Developmental Cell, 2023 - cell.com
Tooth enamel secreted by ameloblasts (AMs) is the hardest material in the human body,
acting as a shield to protect the teeth. However, the enamel is gradually damaged or …

DLP printed hDPSC-loaded GelMA microsphere regenerates dental pulp and repairs spinal cord

Y Qian, J Gong, K Lu, Y Hong, Z Zhu, J Zhang, Y Zou… - Biomaterials, 2023 - Elsevier
Dental pulp regeneration is ideal for irreversible pulp or periapical lesions, and in situ stem
cell therapy is one of the most effective therapies for pulp regeneration. In this study, we …

scFates: a scalable python package for advanced pseudotime and bifurcation analysis from single-cell data

L Faure, R Soldatov, PV Kharchenko… - …, 2023 - academic.oup.com
Abstract Summary scFates provides an extensive toolset for the analysis of dynamic
trajectories comprising tree learning, feature association testing, branch differential …

Lepr‐expressing PDLSCs contribute to periodontal homeostasis and respond to mechanical force by Piezo1

D Zhang, W Lin, S Jiang, P Deng, L Liu… - Advanced …, 2023 - Wiley Online Library
Periodontium supports teeth in a mechanically stimulated tissue environment, where
heterogenous stem/progenitor populations contribute to periodontal homeostasis. In this …

A single-cell atlas of human teeth

P Pagella, L de Vargas Roditi, B Stadlinger, AE Moor… - Iscience, 2021 - cell.com
Teeth exert fundamental functions related to mastication and speech. Despite their great
biomedical importance, an overall picture of their cellular and molecular composition is still …

KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions, and their impairment causes aplasia cutis

JR Raymundo, H Zhang, G Smaldone… - The Journal of …, 2024 - Am Soc Clin Investig
Aplasia cutis congenita (ACC) is a congenital epidermal defect of the midline scalp and has
been proposed to be due to a primary keratinocyte abnormality. Why it forms mainly at this …