The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review

N Akhtar, A Ahad, RK Khar, M Jaggi, M Aqil… - Expert opinion on …, 2011 - Taylor & Francis
Introduction: The ATP-binding cassette superfamily contains membrane transporter proteins
that transport a wide range of diverse compounds across cellular membranes. The P …

Transcription factors that mediate epithelial–mesenchymal transition lead to multidrug resistance by upregulating ABC transporters

M Saxena, MA Stephens, H Pathak… - Cell death & disease, 2011 - nature.com
Abstract Development of multidrug resistance (MDR) is a major deterrent in the effective
treatment of metastatic cancers by chemotherapy. Even though MDR and cancer …

[HTML][HTML] Use of genome-scale metabolic models for understanding microbial physiology

L Liu, R Agren, S Bordel, J Nielsen - FEBS letters, 2010 - Elsevier
The exploitation of microorganisms in industrial, medical, food and environmental
biotechnology requires a comprehensive understanding of their physiology. The availability …

ABC transporter efflux pumps: a defense mechanism against ivermectin in Rhipicephalus (Boophilus) microplus

PC Pohl, GM Klafke, DD Carvalho, JR Martins… - International journal for …, 2011 - Elsevier
ATP-binding cassette (ABC) transporters are efflux transporters found in all organisms.
These proteins are responsible for pumping xenobiotic and endogenous metabolites …

Genome-wide identification and expression profiling of ATP-binding cassette (ABC) transporter gene family in pineapple (Ananas comosus (L.) Merr.) reveal the role …

P Chen, Y Li, L Zhao, Z Hou, M Yan, B Hu… - Frontiers in plant …, 2017 - frontiersin.org
Pineapple (Ananas comosus L.) cultivation commonly relies on asexual reproduction which
is easily impeded by many factors in agriculture production. Sexual reproduction might be a …

ATP binding cassette transporter mediates both heme and pesticide detoxification in tick midgut cells

FA Lara, PC Pohl, AC Gandara, JS Ferreira… - Plos one, 2015 - journals.plos.org
In ticks, the digestion of blood occurs intracellularly and proteolytic digestion of hemoglobin
takes place in a dedicated type of lysosome, the digest vesicle, followed by transfer of the …

MMP2-sensitive PEG–lipid copolymers: a new type of tumor-targeted P-glycoprotein inhibitor

Z Dai, Q Yao, L Zhu - ACS applied materials & interfaces, 2016 - ACS Publications
Low tumor targetability and multidrug resistance (MDR) are two major impediments to the
success of cancer treatments. Nanomaterials which possess high tumor targetability and the …

Response characteristics of indigenous microbial community in polycyclic aromatic hydrocarbons (PAHs) contaminated aquifers under polyethylene microplastics …

Y Ding, J Wang, Y Zhang, Y Zhang, W Xu… - Science of The Total …, 2023 - Elsevier
To understand the response characteristics of indigenous microbial community in PAH-
contaminated aquifers to the coexistence of microplastics. In this paper, we constructed a …

Interaction of immunosuppressive drugs with human organic anion transporter (OAT) 1 and OAT3, and multidrug resistance-associated protein (MRP) 2 and MRP4

AAK El-Sheikh, R Greupink, HM Wortelboer… - Translational …, 2013 - Elsevier
Renal proximal tubule transporters can play a key role in excretion, pharmacokinetic
interactions, and toxicity of immunosuppressant drugs. Basolateral organic anion …

[HTML][HTML] Stress response characteristics of indigenous microorganisms in aromatic-hydrocarbons-contaminated groundwater in the cold regions of Northeast China

J Wang, Y Zhang, Y Ding, H Song, T Liu, W Xu… - Ecotoxicology and …, 2022 - Elsevier
The resistance mechanism of microbial communities in contaminated groundwater under
combined stresses of aromatic hydrocarbons (AHs), NH 4+, and Fe–Mn exceeding standard …