Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and
synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central …

Purpose: Low level laser therapy (LLLT) in the visible to near infrared spectral band (390–
1100 nm) is absorption of laser light at the electronic level, without generation of heat. It may …

Pain is the dominant symptom in osteoarthritis (OA) and sensitization may contribute to the
pain severity. This study investigated the role of sensitization in patients with painful knee …

OBJECTIVES: To discuss fibromyalgia syndrome (FMS) and overlapping conditions, eg,
irritable bowel syndrome, headaches, and chronic fatigue syndrome, within the concept of …

Central sensitization plays an important role in the pathophysiology of numerous
musculoskeletal pain disorders, yet it remains unclear how manual therapists can recognize …

Quantification of the human painful sensory experience is an essential step in the translation
of knowledge from animal nociception to human pain. Translational models for assessment …

In addition to the debilitating fatigue, the majority of patients with chronic fatigue syndrome
(CFS) experience chronic widespread pain. These pain complaints show the greatest …

Even though nociceptive pathology has often long subsided, the brain of patients with
chronic musculoskeletal pain has typically acquired a protective (movement-related) pain …

Background and objectives It has been suggested that sensitization of the central nervous
system plays an important role in the development and maintenance of chronic (pain) …

Hypersensitivity to a variety of sensory stimuli is a feature of persistent whiplash associated
disorders (WAD). However, little is known about sensory disturbances from the time of injury …