Background: The surfaces of the bones in the knee are covered with articular cartilage, a
rubber-like substance that is very smooth, allowing frictionless movement in the joint and …

Osteoarthritis (OA) represents a final and common pathway for all major traumatic insults to
synovial joints. OA is the most common form of degenerative joint disease and a major …

Background: The management of cartilage and osteochondral lesions in the knee remains
problematic and controversial. Our group reported the 2-year and 5-year results of a …

Purpose To provide a systematic review of the clinical literature reporting the efficacy of
mesenchymal stem cells (MSCs) in terms of clinical outcomes including pain and function …

Articular cartilage is composed of chondrons within a territorial matrix surrounded by a
highly organized extracellular matrix comprising collagen II fibrils, proteoglycans …

Purpose To (1) evaluate long-term outcomes of osteochondral allograft (OCA) with regard to
clinical outcome scores, reoperation and failure rates, and (2) examine if certain factors …

Background: Treating articular cartilage defects is a demanding problem. Although several
studies have reported durable and improved clinical outcomes after autologous chondrocyte …

Background: Chondral and osteochondral lesions are being detected with increasing
frequency. For large-diameter lesions, cell-based treatment modalities are speculated to …

Objective Autologous chondrocyte implantation (ACI) has not been proven to be durable
over the long-term. The purpose of this systematic review was (1) to evaluate activity level …

Human bone marrow (BM) is a kind of source of mesenchymal stem cells (MSCs) as well as
growth factors and cytokines that may aid anti-inflammation and regeneration for various …