Transmembrane receptors allow a cell to communicate with its environment in response to a
variety of input signals. These can be changes in the concentration of ligands (eg hormones …

C-type natriuretic peptide (CNP) is an autocrine and paracrine mediator released by
endothelial cells, cardiomyocytes and fibroblasts that regulates vital physiological functions …

Atrial natriuretic peptide (ANP) is a cardiac hormone belonging to the family of natriuretic
peptides (NPs). ANP exerts diuretic, natriuretic, and vasodilatory effects that contribute to …

Natriuretic peptides (NPs), including atrial, brain and C‐type natriuretic peptides (ANP, BNP
and CNP), bind two classes of cell surface receptors: the guanylyl cyclase‐linked A and B …

The accumulation of aggregates of amyloidogenic peptides is associated with numerous
human diseases. One well studied example is the association between deposition of …

Among the three natriuretic peptides, atrial/A-type natriuretic peptide (ANP) and brain/B-type
natriuretic peptide (BNP) are primarily produced by, and secreted from, heart tissue. They …

Repulsive signaling by Semaphorins and Plexins is crucial for the development and
homeostasis of the nervous, immune, and cardiovascular systems. Sema7A acts as both an …

Cyclic GMP is a ubiquitous second messenger that regulates a wide array of physiologic
processes such as blood pressure, long bone growth, intestinal fluid secretion …

Previous studies suggested a beneficial effect of natriuretic peptides in animal models of
cardiovascular disease, but the role of natriuretic peptide receptor C (NPRC) in the …

The crystal structure of the β2-adrenergic receptor in complex with an agonist and its
cognate G protein has just recently been determined. It is now possible to explore in …