With the increase in the ageing population, neurodegenerative disease is devastating to
families and poses a huge burden on society. The brain and spinal cord are extraordinarily …

Newly synthesized transmembrane proteins undergo a series of steps to ensure that only
the required amount of correctly folded protein is localized to the membrane. The regulation …

A prominent feature of late-onset neurodegenerative diseases is accumulation of misfolded
protein in vulnerable neurons. When levels of misfolded protein overwhelm degradative …

Huntington's disease (HD) is characterized by the accumulation of a pathogenic protein,
Huntingtin (Htt), that contains an abnormal polyglutamine expansion. Here, we report that a …

The small ubiquitin-related modifier SUMO posttranslationally modifies many proteins with
roles in diverse processes including regulation of transcription, chromatin structure, and …

Many neurodegenerative diseases are caused by intracellular, aggregate-prone proteins,
including polyglutamine-expanded huntingtin in Huntington's disease (HD) and mutant tau …

Among many achievements in the neurodegeneration field in the past decade, two require
special attention due to the huge impact on our understanding of molecular and cellular …

Sumoylation is an important post-translational modification that provides a rapid and
reversible means for controlling the activity, subcellular localization, and stability of target …

Human neurodegenerative diseases are devastating illnesses that predominantly affect
elderly people. The majority of the diseases are associated with pathogenic oligomers from …

Fragile X syndrome carriers have FMR1 alleles, called premutations, with an intermediate
number of 5′ untranslated CGG repeats between patients (> 200 repeats) and normal …