The primary cilium is a hair-like surface-exposed organelle of the eukaryotic cell that
decodes a variety of signals—such as odorants, light and Hedgehog morphogens—by …

Primary cilia are solitary, immotile sensory organelles present on most cells in the body that
participate broadly in human health, physiology and disease. Cilia generate a unique …

Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are
required to develop models of its actions in cells. Studying a protein family in the aggregate …

Small G-proteins of the ADP-ribosylation-factor-like (Arl) subfamily have been shown to be
crucial to ciliogenesis and cilia maintenance. Active Arl3 is involved in targeting and …

Vision is the most fundamental of our senses initiated when photons are absorbed by the
rod and cone photoreceptor neurons of the retina. At the distal end of each photoreceptor …

The protozoan parasite Leishmania possesses a single flagellum, which is remodelled
during the parasite's life cycle from a long motile flagellum in promastigote forms in the sand …

Asymmetric cell division plays a crucial role in cell differentiation, unequal replicative
senescence, and stem cell maintenance. In budding yeast, the identities of mother and …

Primary cilia contain specific receptors and channel proteins that sense the extracellular
milieu. Defective ciliary function causes ciliopathies such as autosomal dominant polycystic …

Primary cilia act as cell surface antennae, coordinating cellular responses to sensory inputs
and signalling molecules that regulate developmental and homeostatic pathways. Cilia are …

Joubert syndrome (JBTS) is a genetically heterogeneous autosomal-recessive
neurodevelopmental ciliopathy. We investigated further the underlying genetic etiology of …