One of the most consistent genetic findings to have emerged from bipolar disorder genome
wide association studies (GWAS) is with CACNA1C, a gene that codes for the α1C subunit …

Calcium influx through voltage-gated Ca (CaV) channels is the first step in synaptic
transmission. This review concerns CaV channels at ribbon synapses in primary sense …

Genome-wide association studies (GWASs) have identified> 100 susceptibility loci for
schizophrenia (SCZ) and demonstrated that SCZ is a polygenic disorder determined by …

Calcium signaling in neurons as in other cell types can lead to varied changes in cellular
function. Neuronal Ca2+ signaling processes have also become adapted to modulate the …

BACKGROUND: Voltage-gated (Cav) Ca2+ channels are multi-subunit complexes that play
diverse roles in a wide variety of tissues. A fundamental mechanism controlling Cav channel …

Voltage-and ligand-gated ion channels form the molecular basis of cellular excitability.
With> 400 members and accounting for∼ 1.5% of the human genome, ion channels are …

The calcium-binding protein calmodulin (CaM) directly binds to membrane transport proteins
to modulate their function in response to changes in intracellular calcium concentrations …

Background Calmodulin (CaM) mutations are associated with cardiac arrhythmia
susceptibility including congenital long QT syndrome (LQTS). Objective The purpose of this …

L-type voltage-gated Ca2+ channels (CaV1. 2 and CaV1. 3, called CaV) interact with the
Ca2+ sensor proteins, calmodulin (CaM) and Ca2+ binding Protein 1 (CaBP1), that …

Summary Within neurons, Ca 2+-dependent inactivation (CDI) of voltage-gated L-type Ca 2+
channels shapes cytoplasmic Ca 2+ signals. CDI is initiated by Ca 2+ binding to channel …