Named entity recognition and relation detection for biomedical information extraction
The number of scientific publications in the literature is steadily growing, containing our
knowledge in the biomedical, health, and clinical sciences. Since there is currently no …
knowledge in the biomedical, health, and clinical sciences. Since there is currently no …
In silico ADME/T modelling for rational drug design
Y Wang, J Xing, Y Xu, N Zhou, J Peng… - Quarterly reviews of …, 2015 - cambridge.org
In recent decades, in silico absorption, distribution, metabolism, excretion (ADME), and
toxicity (T) modelling as a tool for rational drug design has received considerable attention …
toxicity (T) modelling as a tool for rational drug design has received considerable attention …
Comparative toxicogenomics database (CTD): update 2021
AP Davis, CJ Grondin, RJ Johnson… - Nucleic acids …, 2021 - academic.oup.com
Abstract The public Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) is an
innovative digital ecosystem that relates toxicological information for chemicals, genes …
innovative digital ecosystem that relates toxicological information for chemicals, genes …
The comparative toxicogenomics database: update 2019
AP Davis, CJ Grondin, RJ Johnson… - Nucleic acids …, 2019 - academic.oup.com
Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) is a premier
public resource for literature-based, manually curated associations between chemicals …
public resource for literature-based, manually curated associations between chemicals …
A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information
Y Luo, X Zhao, J Zhou, J Yang, Y Zhang… - Nature …, 2017 - nature.com
The emergence of large-scale genomic, chemical and pharmacological data provides new
opportunities for drug discovery and repositioning. In this work, we develop a computational …
opportunities for drug discovery and repositioning. In this work, we develop a computational …
The support of human genetic evidence for approved drug indications
Over a quarter of drugs that enter clinical development fail because they are ineffective.
Growing insight into genes that influence human disease may affect how drug targets and …
Growing insight into genes that influence human disease may affect how drug targets and …
The comparative toxicogenomics database: update 2017
AP Davis, CJ Grondin, RJ Johnson… - Nucleic acids …, 2017 - academic.oup.com
Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) provides
information about interactions between chemicals and gene products, and their …
information about interactions between chemicals and gene products, and their …
DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes
DisGeNET is a comprehensive discovery platform designed to address a variety of
questions concerning the genetic underpinning of human diseases. DisGeNET contains …
questions concerning the genetic underpinning of human diseases. DisGeNET contains …
Understanding multicellular function and disease with human tissue-specific networks
Tissue and cell-type identity lie at the core of human physiology and disease. Understanding
the genetic underpinnings of complex tissues and individual cell lineages is crucial for …
the genetic underpinnings of complex tissues and individual cell lineages is crucial for …
[HTML][HTML] NeoDTI: neural integration of neighbor information from a heterogeneous network for discovering new drug–target interactions
Results Inspired by recent advance of information passing and aggregation techniques that
generalize the convolution neural networks to mine large-scale graph data and greatly …
generalize the convolution neural networks to mine large-scale graph data and greatly …