Background Concerns regarding the safety of transfused blood have led to the development
of a range of interventions to minimise blood loss during major surgery. Anti‐fibrinolytic …

THE purpose of this review is to evaluate recent developments in our understanding of the
inflammatory response to cardiac surgery. Scientific knowledge in this field is continually …

BACKGROUND: A minority of patients having cardiac procedures (15% to 20%) consume
more than 80% of the blood products transfused at operation. Blood must be viewed as a …

When bleeding is the consequence of a specific defect of hemostasis, the goal of treatment
is to correct the defect. A typical example is the replacement of factor VIII by transfusion in …

The most common medical cause of major blood loss is surgery, particularly cardiovascular
procedures, liver transplantation and hepatic resection, and major orthopedic procedures …

Background. We sought to investigate the effect of multiple coronary artery bypass grafting
(CABG) with or without cardiopulmonary bypass (CPB) on the perioperative inflammatory …

Background Excessive bleeding may complicate cardiac surgery, and is associated with
increased morbidity and mortality. Pharmacological strategies to decrease perioperative …

Background—Since the 1980s, antifibrinolytic therapies have assisted surgical teams in
reducing the amount of blood loss. To date, however, serious questions remain regarding …

Background. Coronary revascularization with cardiopulmonary bypass has the potential risk
of renal dysfunction related to the nonphysiologic nature of cardiopulmonary bypass …

Background Various methods have been used to try to protect kidney function in patients
undergoing surgery. These most often include pharmacological interventions such as …