The failure of animal models to predict therapeutic responses in humans is a major problem
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …

Cell culture is an important and necessary process in drug discovery, cancer research, as
well as stem cell study. Most cells are currently cultured using two-dimensional (2D) …

One of the problems that has slowed the development and approval of new anticancer
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …

For the past century, experimental data obtained from animal studies have been required by
reviewers of scientific articles and grant applications to validate the physiological relevance …

Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …

The diverse bacterial populations that comprise the commensal microbiome of the human
intestine play a central role in health and disease. A method that sustains complex microbial …

Organ chips can recapitulate organ-level (patho) physiology, yet pharmacokinetic and
pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here …

Microfluidic organ-on-a-chip models of human intestine have been developed and used to
study intestinal physiology and pathophysiology. In this article, we review this field and …

Organ-on-A-chip (OoAC) devices are miniaturized, functional, in vitro constructs that aim to
recapitulate the in vivo physiology of an organ using different cell types and extracellular …

The initiation of intestinal inflammation involves complex intercellular cross-talk of
inflammatory cells, including the epithelial and immune cells, and the gut microbiome. This …