[HTML][HTML] Biosynthesis and metabolism of endocannabinoids and their congeners from the monoacylglycerol and N-acyl-ethanolamine families
Abstract The endocannabinoids 2-arachidonoyl-glycerol (2-AG) and N-arachidonoyl-
ethanolamine (AEA) are eicosanoids implicated in numerous physiological processes like …
ethanolamine (AEA) are eicosanoids implicated in numerous physiological processes like …
[HTML][HTML] High levels of eicosanoids and docosanoids in the lungs of intubated COVID‐19 patients
Severe acute respiratory syndrome coronavirus 2 is responsible for coronavirus disease
2019 (COVID‐19). While COVID‐19 is often benign, a subset of patients develops severe …
2019 (COVID‐19). While COVID‐19 is often benign, a subset of patients develops severe …
The immune endocannabinoid system of the tumor microenvironment
M Kienzl, J Kargl, R Schicho - International Journal of Molecular Sciences, 2020 - mdpi.com
Leukocytes are part of the tumor microenvironment (TME) and are critical determinants of
tumor progression. Because of the immunoregulatory properties of cannabinoids, the …
tumor progression. Because of the immunoregulatory properties of cannabinoids, the …
Cytokines and lipid mediators of inflammation in lungs of SARS-CoV-2 infected mice
I Dubuc, J Prunier, É Lacasse, A Gravel… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 19 (COVID-19) is the clinical manifestation of severe acute respiratory
syndrome Coronavirus 2 (SARS-CoV-2) infection. A hallmark of COVID-19 is a lung …
syndrome Coronavirus 2 (SARS-CoV-2) infection. A hallmark of COVID-19 is a lung …
The role of cannabinoids in allergic diseases: Collegium Internationale Allergologicum (CIA) update 2020
A Angelina, M Pérez-Diego, J López-Abente… - International archives of …, 2020 - karger.com
The human endocannabinoid system (ECS) is a complex signalling network involved in
many key physiological processes. The ECS includes the cannabinoid receptors, the …
many key physiological processes. The ECS includes the cannabinoid receptors, the …
Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer
M Kienzl, C Hasenoehrl, K Maitz… - …, 2021 - Taylor & Francis
Monoacylglycerol lipase (MGL) expressed in cancer cells influences cancer pathogenesis
but the role of MGL in the tumor microenvironment (TME) is less known. Using a syngeneic …
but the role of MGL in the tumor microenvironment (TME) is less known. Using a syngeneic …
Probing the Interactions of Thiazole Abietane Inhibitors with the Human Serine Hydrolases ABHD16A and ABHD12
TJ Ahonen, CP Ng, B Farinha, B Almeida… - ACS Medicinal …, 2023 - ACS Publications
12-Thiazole abietanes are highly selective reversible inhibitors of hABHD16A that could
potentially alleviate neuroinflammation. In this study, we used synthetic chemistry …
potentially alleviate neuroinflammation. In this study, we used synthetic chemistry …
Endocannabinoid hydrolysis inhibition unmasks that unsaturated fatty acids induce a robust biosynthesis of 2‐arachidonoyl‐glycerol and its congeners in human …
C Turcotte, AS Archambault, E Dumais… - The FASEB …, 2020 - Wiley Online Library
Abstract The endocannabinoid (eCB) 2‐arachidonoyl‐gycerol (2‐AG) modulates immune
responses by activating cannabinoid receptors or through its multiple metabolites, notably …
responses by activating cannabinoid receptors or through its multiple metabolites, notably …
Biosynthesis of the Novel Endogenous 15-Lipoxygenase Metabolites N-13-Hydroxy-octodecadienoyl-ethanolamine and 13-Hydroxy-octodecadienoyl-glycerol by …
The endocannabinoids 2-arachidonoyl-glycerol and N-arachidonoyl-ethanolamine are
lipids regulating many physiological processes, notably inflammation. Endocannabinoid …
lipids regulating many physiological processes, notably inflammation. Endocannabinoid …
Hepatic NAPE-PLD is a key regulator of liver lipid metabolism
Diverse metabolic disorders have been associated with an alteration of N-acylethanolamine
(NAE) levels. These bioactive lipids are synthesized mainly by N …
(NAE) levels. These bioactive lipids are synthesized mainly by N …