Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …

Ewing sarcoma (ES) is an aggressive sarcoma of bone and soft tissue occurring at any age
with a peak incidence in adolescents and young adults. The treatment of ES relies on a …

Primary bone tumours are rare, accounting for< 0.2% of malignant neoplasms registered in
the EUROCARE (European Cancer Registry based study on survival and care of cancer …

Exciting therapeutic targets are emerging from CRISPR-based screens of high mutational-
burden adult cancers. A key question, however, is whether functional genomic approaches …

Pediatric Ewing sarcoma is characterized by the expression of chimeric fusions of EWS and
ETS family transcription factors, representing a paradigm for studying cancers driven by …

Purpose Chemotherapy with alternating vincristine-doxorubicin-cyclophosphamide and
ifosfamide-etoposide cycles and primary tumor treatment with surgery and/or radiation …

The NCCN Guidelines for Bone Cancer provide interdisciplinary recommendations for
treating chordoma, chondrosarcoma, giant cell tumor of bone, Ewing sarcoma, and …

Purpose This report provides an overview of current childhood cancer statistics to facilitate
analysis of the impact of past research discoveries on outcome and provide essential …

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, and can be
subcategorized histologically and/or based on PAX-FOXO1 fusion gene status. Over the last …

Progress in the treatment of Ewing's sarcoma, the second most common bone tumour in
children and adolescents, has improved survival from about 10% in the period before …