Despite all the other cells that have the potential to prevent cancer development and
metastasis through tumour suppressor proteins, cancer cells can upregulate the ubiquitin …

Abstract Ubiquitin Proteasome System (UPS) is an adaptable and finely tuned system that
sustains proteostasis network under a large variety of physiopathological conditions. Its …

The proteasome is responsible for mediating intracellular protein degradation and
regulating cellular function with impact on tumor and immune effector cell biology. The …

Gliomas constitute the most frequent tumors of the brain. High-grade gliomas are
characterized by a poor prognosis caused by a set of attributes making treatment difficult …

Long noncoding RNAs (lncRNAs) are RNA molecules comprising more than 200
nucleotides, which are not translated into proteins. Many studies have shown that lncRNAs …

Lysosomal-dependent self-degradative (autophagic) mechanisms are essential for the
maintenance of normal homeostasis in all eukaryotic cells. Several types of such self …

Oxidative stress is a major cause of morbidity and mortality in human health and disease. In
this review, we focus on the Forkhead Box (Fox) subclass O3 (FoxO3), an extensively …

Loss of proteome fidelity leads to the accumulation of non-native protein aggregates and
oxidatively damaged species: hallmarks of an aged cell. These misfolded and aggregated …

Major histocompatibility complex class I (MHC I) plays a crucial role in the development of
adaptive immune response in vertebrates. MHC molecules are cell surface protein …

In this study, we have asked whether proteasome composition and function are affected in
cells derived from patients suffering from all types of mucopolysaccharidosis (MPS), an …