Involvement of the central nervous system in acute lymphoblastic leukemia: opinions on molecular mechanisms and clinical implications based on recent data
L Lenk, A Alsadeq, DM Schewe - Cancer and Metastasis Reviews, 2020 - Springer
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. One of the major
clinical challenges is adequate diagnosis and treatment of central nervous system (CNS) …
clinical challenges is adequate diagnosis and treatment of central nervous system (CNS) …
Linking pesticide exposure with pediatric leukemia: potential underlying mechanisms
AF Hernández, P Menéndez - International journal of molecular sciences, 2016 - mdpi.com
Leukemia is the most common cancer in children, representing 30% of all childhood
cancers. The disease arises from recurrent genetic insults that block differentiation of …
cancers. The disease arises from recurrent genetic insults that block differentiation of …
Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia
D Sánchez-Martínez, ML Baroni… - Blood, The Journal …, 2019 - ashpublications.org
Relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) has a dismal outcome, and
no effective targeted immunotherapies for T-ALL exist. The extension of chimeric antigen …
no effective targeted immunotherapies for T-ALL exist. The extension of chimeric antigen …
[HTML][HTML] Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis
A Agraz-Doblas, C Bueno, R Bashford-Rogers… - …, 2019 - ncbi.nlm.nih.gov
B-cell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell
acute lymphoblastic leukemia remains fatal, especially in patients with t (4; 11), present in …
acute lymphoblastic leukemia remains fatal, especially in patients with t (4; 11), present in …
Mouse models of MLL leukemia: recapitulating the human disease
TA Milne - Blood, The Journal of the American Society of …, 2017 - ashpublications.org
Chromosome translocations involving the mixed lineage leukemia (MLL) gene fuse it in
frame with multiple partner genes creating novel fusion proteins (MLL-FPs) that cause …
frame with multiple partner genes creating novel fusion proteins (MLL-FPs) that cause …
Molecular processes involved in B cell acute lymphoblastic leukaemia
C Malouf, K Ottersbach - Cellular and molecular life sciences, 2018 - Springer
B cell leukaemia is one of the most frequent malignancies in the paediatric population, but
also affects a significant proportion of adults in developed countries. The majority of infant …
also affects a significant proportion of adults in developed countries. The majority of infant …
Detailed characterization of mesenchymal stem/stromal cells from a large cohort of AML patients demonstrates a definitive link to treatment outcomes
RD de la Guardia, B Lopez-Millan, JR Lavoie, C Bueno… - Stem Cell Reports, 2017 - cell.com
Bone marrow mesenchymal stem/stromal cells (BM-MSCs) are key components of the
hematopoietic niche thought to have a direct role in leukemia pathogenesis. BM-MSCs from …
hematopoietic niche thought to have a direct role in leukemia pathogenesis. BM-MSCs from …
Respecifying human iPSC-derived blood cells into highly engraftable hematopoietic stem and progenitor cells with a single factor
YT Tan, L Ye, F Xie, AI Beyer… - Proceedings of the …, 2018 - National Acad Sciences
Derivation of human hematopoietic stem cells (HSCs) from induced pluripotent stem cells
(iPSCs) offers considerable promise for cell therapy, disease modeling, and drug screening …
(iPSCs) offers considerable promise for cell therapy, disease modeling, and drug screening …
NKG2D-CAR memory T cells target pediatric T-cell acute lymphoblastic leukemia in vitro and in vivo but fail to eliminate leukemia initiating cells
M Ibáñez-Navarro, A Fernandez, A Escudero… - Frontiers in …, 2023 - frontiersin.org
Introduction Refractory/relapsed pediatric acute leukemia are still clinically challenging and
new therapeutic strategies are needed. Interactions between Natural Killer Group 2D …
new therapeutic strategies are needed. Interactions between Natural Killer Group 2D …
CD19-CAR-T Cells Bearing a KIR/PD-1-Based Inhibitory CAR Eradicate CD19+HLA-C1− Malignant B Cells While Sparing CD19+HLA-C1+ Healthy B Cells
L Tao, MA Farooq, Y Gao, L Zhang, C Niu, I Ajmal… - Cancers, 2020 - mdpi.com
Simple Summary CD19-targeted chimeric antigen receptor (CAR) T (CD19-CAR-T) cell
therapy usually causes B cell aplasia because of “on-target off-tumor” toxicity. The aim of the …
therapy usually causes B cell aplasia because of “on-target off-tumor” toxicity. The aim of the …