Virulence factors of the Mycobacterium tuberculosis complex

MA Forrellad, LI Klepp, A Gioffré, J Sabio y Garcia… - Virulence, 2013 - Taylor & Francis
The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

Phylogeny to function: PE/PPE protein evolution and impact on Mycobacterium tuberculosis pathogenicity

S Fishbein, N Van Wyk, RM Warren… - Molecular …, 2015 - Wiley Online Library
The pe/ppe genes represent one of the most intriguing aspects of the M ycobacterium
tuberculosis genome. These genes are especially abundant in pathogenic mycobacteria …

Latent tuberculosis infection: myths, models, and molecular mechanisms

NK Dutta, PC Karakousis - Microbiology and Molecular Biology …, 2014 - Am Soc Microbiol
The aim of this review is to present the current state of knowledge on human latent
tuberculosis infection (LTBI) based on clinical studies and observations, as well as …

Gut microbiome contributes to impairment of immunity in pulmonary tuberculosis patients by alteration of butyrate and propionate producers

A Maji, R Misra, DB Dhakan, V Gupta… - Environmental …, 2018 - Wiley Online Library
Tuberculosis (TB) is primarily associated with decline in immune health status. As gut
microbiome (GM) is implicated in the regulation of host immunity and metabolism, here we …

Non-tuberculous mycobacteria: Molecular and physiological bases of virulence and adaptation to ecological niches

AC Pereira, B Ramos, AC Reis, MV Cunha - Microorganisms, 2020 - mdpi.com
Non-tuberculous mycobacteria (NTM) are paradigmatic colonizers of the total environment,
circulating at the interfaces of the atmosphere, lithosphere, hydrosphere, biosphere, and …

DNA Methylation Impacts Gene Expression and Ensures Hypoxic Survival of Mycobacterium tuberculosis

SS Shell, EG Prestwich, SH Baek, RR Shah… - PLoS …, 2013 - journals.plos.org
DNA methylation regulates gene expression in many organisms. In eukaryotes, DNA
methylation is associated with gene repression, while it exerts both activating and repressive …

Widespread suppression of intragenic transcription initiation by H-NS

SS Singh, N Singh, RP Bonocora… - Genes & …, 2014 - genesdev.cshlp.org
Widespread intragenic transcription initiation has been observed in many species. Here we
show that the Escherichia coli ehxCABD operon contains numerous intragenic promoters in …

The mycobacterial transcriptional regulator whiB7 gene links redox homeostasis and intrinsic antibiotic resistance

J Burian, S Ramón-García, G Sweet… - Journal of Biological …, 2012 - ASBMB
Intrinsic drug resistance in Mycobacterium tuberculosis limits therapeutic options for treating
tuberculosis. The mycobacterial transcriptional regulator whiB7 contributes to intrinsic …

New approaches and therapeutic options for Mycobacterium tuberculosis in a dormant state

S Caño-Muñiz, R Anthony, S Niemann… - Clinical microbiology …, 2018 - Am Soc Microbiol
We are far away from the days when tuberculosis (TB) accounted for 1 in 4 deaths during the
19th century. However, Mycobacterium tuberculosis complex (MTBC) strains are still the …

Sigma factors and promoters in Corynebacterium glutamicum

M Pátek, J Nešvera - Journal of biotechnology, 2011 - Elsevier
The Corynebacterium glutamicum genome codes for 7 sigma subunits (factors) of RNA
polymerase (RNAP): primary sigma factor SigA (σA), primary-like SigB and 5 other …