Recent progress of targeted G-quadruplex-preferred ligands toward cancer therapy
A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-
rich sequences, and has profound implications for various pharmacological and biological …
rich sequences, and has profound implications for various pharmacological and biological …
G-quadruplex DNA: a novel target for drug design
FY Teng, ZZ Jiang, M Guo, XZ Tan, F Chen… - Cellular and Molecular …, 2021 - Springer
Abstract G-quadruplex (G4) DNA is a type of quadruple helix structure formed by a
continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated …
continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated …
i-Motif DNA: structure, stability and targeting with ligands
HA Day, P Pavlou, ZAE Waller - Bioorganic & medicinal chemistry, 2014 - Elsevier
Abstract i-Motifs are four-stranded DNA secondary structures which can form in sequences
rich in cytosine. Stabilised by acidic conditions, they are comprised of two parallel-stranded …
rich in cytosine. Stabilised by acidic conditions, they are comprised of two parallel-stranded …
Making sense of G‐quadruplex and i‐motif functions in oncogene promoters
The presence and biological importance of DNA secondary structures in eukaryotic
promoters are becoming increasingly recognized among chemists and biologists as …
promoters are becoming increasingly recognized among chemists and biologists as …
Transcriptional regulation of bcl-2 by nuclear factor κB and its significance in prostate cancer
SD Catz, JL Johnson - Oncogene, 2001 - nature.com
This work presents direct evidence that the bcl-2 gene is transcriptionally regulated by
nuclear factor-κB (NF-κB) and directly links the TNF-α/NF-κB signaling pathway with Bcl-2 …
nuclear factor-κB (NF-κB) and directly links the TNF-α/NF-κB signaling pathway with Bcl-2 …
A tumor suppressor and oncogene: the WT1 story
L Yang, Y Han, F Saurez Saiz, MD Minden - Leukemia, 2007 - nature.com
Abstract The Wilms' tumor 1 (WT1) gene encodes a transcription factor important for normal
cellular development and cell survival. The initial discovery of WT1 as the causative gene in …
cellular development and cell survival. The initial discovery of WT1 as the causative gene in …
Structural insights into G-quadruplexes: towards new anticancer drugs
D Yang, K Okamoto - Future medicinal chemistry, 2010 - Taylor & Francis
DNA G-quadruplexes are DNA secondary structures formed in specific G-rich sequences.
DNA sequences that can form G-quadruplexes have been found in regions with biological …
DNA sequences that can form G-quadruplexes have been found in regions with biological …
An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solution
J Dai, TS Dexheimer, D Chen, M Carver… - Journal of the …, 2006 - ACS Publications
We report the first G-quadruplex structure formed in the promoter region of the human bcl-2.
Bcl-2 is a potent oncoprotein that functions as an inhibitor of cell apoptosis and has been …
Bcl-2 is a potent oncoprotein that functions as an inhibitor of cell apoptosis and has been …
Deconvoluting the Structural and Drug-Recognition Complexity of the G-Quadruplex-Forming Region Upstream of the bcl-2 P1 Promoter
TS Dexheimer, D Sun, LH Hurley - Journal of the American …, 2006 - ACS Publications
The human bcl-2 gene contains a GC-rich region upstream of the P1 promoter that has been
shown to be critically involved in the regulation of bcl-2 gene expression. We have …
shown to be critically involved in the regulation of bcl-2 gene expression. We have …
NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region
ABSTRACT BCL2 protein functions as an inhibitor of cell apoptosis and has been found to
be aberrantly expressed in a wide range of human diseases. A highly GC-rich region …
be aberrantly expressed in a wide range of human diseases. A highly GC-rich region …