Mitochondrial fusion, fission, and mitochondrial toxicity

JN Meyer, TC Leuthner, AL Luz - Toxicology, 2017 - Elsevier
Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial
fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as …

Melatonin: a mitochondrial targeting molecule involving mitochondrial protection and dynamics

DX Tan, LC Manchester, L Qin, RJ Reiter - International journal of …, 2016 - mdpi.com
Melatonin has been speculated to be mainly synthesized by mitochondria. This speculation
is supported by the recent discovery that aralkylamine N-acetyltransferase/serotonin N …

Pineal calcification, melatonin production, aging, associated health consequences and rejuvenation of the pineal gland

DX Tan, B Xu, X Zhou, RJ Reiter - Molecules, 2018 - mdpi.com
The pineal gland is a unique organ that synthesizes melatonin as the signaling molecule of
natural photoperiodic environment and as a potent neuronal protective antioxidant. An intact …

Protective role of melatonin in cardiac ischemia‐reperfusion injury: From pathogenesis to targeted therapy

H Zhou, Q Ma, P Zhu, J Ren, RJ Reiter… - Journal of pineal …, 2018 - Wiley Online Library
Acute myocardial infarction (MI) is a major cause of mortality and disability worldwide. In
patients with MI, the treatment option for reducing acute myocardial ischemic injury and …

The main molecular mechanisms underlying methamphetamine-induced neurotoxicity and implications for pharmacological treatment

X Yang, Y Wang, Q Li, Y Zhong, L Chen… - Frontiers in molecular …, 2018 - frontiersin.org
Methamphetamine (METH) is a popular new-type psychostimulant drug with complicated
neurotoxicity. In spite of mounting evidence on METH-induced damage of neural cell, the …

Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms

R Moratalla, A Khairnar, N Simola, N Granado… - Progress in …, 2017 - Elsevier
Amphetamine-related drugs, such as 3, 4-methylenedioxymethamphetamine (MDMA) and
methamphetamine (METH), are popular recreational psychostimulants. Several preclinical …

Increasing Nrf2 activity as a treatment approach in neuropsychiatry

G Morris, AJ Walker, K Walder, M Berk, W Marx… - Molecular …, 2021 - Springer
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor encoded by NFE2L2.
Under oxidative stress, Nrf2 does not undergo its normal cytoplasmic degradation but …

Melatonin and mitochondrial function during ischemia/reperfusion injury

Z Ma, Z Xin, W Di, X Yan, X Li, RJ Reiter… - Cellular and Molecular …, 2017 - Springer
Ischemia/reperfusion (IR) injury occurs in many organs and tissues, and contributes to
morbidity and mortality worldwide. Melatonin, an endogenously produced indolamine …

[HTML][HTML] Mitochondrial dysfunction: A fatal blow in depression

Y Song, H Cao, C Zuo, Z Gu, Y Huang, J Miao… - Biomedicine & …, 2023 - Elsevier
Mitochondria maintain the normal physiological function of nerve cells by producing
sufficient cellular energy and performing crucial roles in maintaining the metabolic balance …

Melatonin prevents abnormal mitochondrial dynamics resulting from the neurotoxicity of cadmium by blocking calcium‐dependent translocation of Drp1 to the …

S Xu, H Pi, L Zhang, N Zhang, YM Li… - Journal of pineal …, 2016 - Wiley Online Library
Cadmium (Cd) is a persistent environmental toxin and occupational pollutant that is
considered to be a potential risk factor in the development of neurodegenerative diseases …