Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …

Drug development is a lengthy and costly process that proceeds through several stages
from target identification to lead discovery and optimization, preclinical validation and …

Natural extracellular matrices (ECMs) are viscoelastic and exhibit stress relaxation.
However, hydrogels used as synthetic ECMs for three-dimensional (3D) culture are typically …

The pulmonary extracellular matrix (ECM) determines the tissue architecture of the lung, and
provides mechanical stability and elastic recoil, which are essential for physiological lung …

Organoid systems leverage the self-organizing properties of stem cells to create diverse
multi-cellular tissue proxies. Most organoid models only represent single or partial …

Bioprinting is rapidly being adopted as a major method for fabricating tissue engineering
constructs. Through the precise deposition of cell-and bioactive molecule-laden materials …

The development of bioinks for bioprinting of cell‐laden constructs remains a challenge for
tissue engineering, despite vigorous investigation. Hydrogels to be used as bioinks must …

Biodegradable polymers play a pivotal role in in situ tissue engineering. Utilizing various
technologies, researchers have been able to fabricate 3D tissue engineering scaffolds using …

Much of our understanding of the biological mechanisms that underlie cellular functions,
such as migration, differentiation and force-sensing has been garnered from studying cells …