Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …

Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

The actin cytoskeleton and associated motor proteins provide the driving forces for
establishing the astonishing morphological diversity and dynamics of mammalian cells …

Tumor cell extravasation is a key step during cancer metastasis, yet the precise mechanisms
that regulate this dynamic process are unclear. We utilized a high-resolution time-lapse …

The dissemination of cancer cells from the primary tumor to a distant site, known as
metastasis, is the main cause of mortality in cancer patients. Metastasis is a very complex …

Invadopodia and podosomes are discrete, actin‐based molecular protrusions that form in
cancer cells and normal cells, respectively, in response to diverse signaling pathways and …

The activation and accumulation of lung fibroblasts resulting in aberrant deposition of
extracellular matrix components, is a pathogenic hallmark of Idiopathic Pulmonary Fibrosis …

Notch regulates cell–cell contact-dependent signaling and is activated by hypoxia, a
microenvironmental condition that promotes cellular invasion during both normal physiology …

Invadopodia-dependent degradation of the basement membrane plays a major role during
metastasis of breast cancer cells. Basement membrane degradation is mediated by targeted …

Osteoclasts fuse to form multinucleated cells during osteoclastogenesis. This process is
mediated by dynamic rearrangement of the plasma membrane and cytoskeleton, and it …