Numerous studies implicate the cyclooxygenase 2 (COX2) enzyme and COX2-derived
prostanoids in various human diseases, and thus, much effort has been made to uncover the …

Nonsteroidal anti-inflammatory drugs represent the most commonly used medications for the
treatment of pain and inflammation, but numerous well-described side effects can limit their …

Overcome the toughest clinical challenges in nephrology with the new 9th edition of
Brenner/Rector's The Kidney! A brand-new editorial team of Drs. Maarten W. Taal, Glenn M …

Objective—Obesity is recognized increasingly as a major risk factor for kidney disease. We
reported previously that plasma adiponectin levels were decreased in obesity, and that …

Previous investigations have demonstrated that green tea polyphenols and partially
hydrolyzed guar gum as dietary fiber have antioxidative and hypolipidemic activity …

Significant reduction of renal mass initiates a series of hemodynamic and nonhemodynamic
events which lead to proteinuria, glomerulosclerosis, tubulointerstitial injury, and end-stage …

Significant reduction of renal mass triggers a chain of events that result in glomerular
hypertension/hyperfiltration, proteinuria, glomerulosclerosis, tubulointerstitial injury, and end …

Chronic renal injury can be mediated by angiotensin II (ANG II) and prostanoids through
hemodynamic and inflammatory mechanisms and attenuated by individual suppression of …

COX‐2/mPGES‐1/PGE2 cascade plays critical roles in modulating many physiological and
pathological actions in different organs. In the kidney, this cascade is of high importance in …

The circadian rhythm regulates blood pressure and maintains fluid and electrolyte
homeostasis with central and peripheral clock. However, the role of circadian rhythm in the …