Decades of research have mapped out the basic mechanics of the Hippo pathway. The
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …

The Hippo signaling pathway inhibits the activity of the oncogenic YAP (Yes-associated
protein)/TAZ (transcriptional co-activator with PDZ-binding motif)–TEAD (TEA/ATTS domain) …

Hippo signaling was first identified in Drosophila as a key controller of organ size by
regulating cell proliferation and anti-apoptosis. Subsequent studies have shown that this …

Breast cancer (BC) is the most commonly diagnosed form of cancer and a leading cause of
cancer-related deaths among women worldwide. Yes-associated protein (YAP) and …

Simple Summary The Hippo pathway is crucial for regulating cell growth, organ size, and
tissue regeneration. When this pathway goes awry, it can lead to uncontrolled cell growth …

Dysregulated ERα signaling is responsible for endocrine resistance and eventual relapse in
patients with estrogen receptor-positive (ER+) breast cancer. Thus, identifying novel ERα …

Hippo signaling restricts tumor growth by inhibiting the oncogenic potential of YAP/TAZ‐
TEAD transcriptional complex. Here, we uncover a context‐dependent tumor suppressor …

The Hippo pathway is generally understood to inhibit tumor growth by phosphorylating the
transcriptional cofactor YAP to sequester it to the cytoplasm and reduce the formation of YAP …

The extracellular matrix (ECM) plays critical roles in cytoskeletal support, biomechanical
transduction and biochemical signal transformation. Tumor-associated macrophage (TAM) …

Induction of cytochrome P450 (CYP) genes constitutes an important cause of drug–drug
interactions and preclinical evaluation of induction liability is mandatory for novel drug …