Mitosis is a delicate event that must be executed with high fidelity to ensure genomic
stability. Recent work has provided insight into how mitotic errors shape cancer genomes by …

Centrosome amplification is a hallmark of cancer. However, despite significant progress in
recent years, we are still far from understanding how centrosome amplification affects …

Chromosomal aberrations during cell division represent one of the first recognized features
of human cancer cells, and modern detection methods have revealed the pervasiveness of …

Over a century ago, centrosome aberrations were postulated to cause cancer by promoting
genome instability. The mechanisms governing centrosome assembly and function are …

Cellular defects that impair the fidelity of mitosis promote chromosome missegregation and
aneuploidy. Increasing evidence reveals that errors in mitosis can also promote the direct …

Mitotic spindle bipolarity is essential for faithful segregation of chromosomes during cell
division. Multipolar spindles are often seen in human cancers and are usually associated …

Historically, cancers have been treated with chemotherapeutics aimed to have profound
effects on tumor cells with only limited effects on normal tissue. This approach was followed …

Background Repurposing antifungal drugs in cancer therapy has attracted unprecedented
attention in both preclinical and clinical research due to specific advantages, such as safety …

Polo-like kinases (Plks) are critical regulatory molecules during the cell cycle process. This
family has five members: Plk1, 2, 3, 4, and 5. Plk4 has been identified as a master regulator …

The natural product griseofulvin,(2S, 6′ R)-7-chloro-4, 6-dimethoxybenzofuran-3-one-2-
spiro-1′-(2′-methoxy-6′-methylcyclohex-2′-en-4′-one)(1, Figure 1), has a rich …